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Understanding Causes and Outcomes of Acute Diarrhea in Severely Malnourished Children

Clinicoetiological spectrum and outcomes of children with acute diarrhea and severe acute malnutrition - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/09/094106
Enrollment
80
Registered
2025-09-02
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E43- Unspecified severe protein-caloriemalnutrition

Interventions

Intervention1: NIL: NIL Control Intervention1: Nil: Nil

Sponsors

Maulana Azad Medical College and Lok Nayak Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Group 1 : Children aged 6 months to 5 years diagnosed with acute diarrhea (less than or equal to 14 days duration) with SAM ( as per WHO criteria). Group 2: SAM children without diarrhea needing hospitalization .

Exclusion criteria

Exclusion criteria: 1.Chronic diarrhea . 2.Congenital or metabolic disorders affecting growth or gut function. 3.Re-admissions or referred cases after treatment elsewhere. 4.Coexisting chronic systemic illness (e.g. chronic heart, kidney, hematological, liver, or gastrointestinal disease), known primary/acquired immunodeficiency or immunosuppression.

Design outcomes

Primary

MeasureTime frame
Primary outcome variable: Difference in mean duration of hospital stay between children with acute diarrhea and severe acute malnutrition and those with SAM and Hospitalization.Timepoint: 1 week—

Secondary

MeasureTime frame
1.Median duration in clinical rehydration (in hours) and stool recovery (Bristol 5 or less) between the two groups. 2.Proportion of bacterial and parasitic pathogen in stool sample from Group 1. 3.Frequency and pattern of clinical symptoms (e.g., fever, vomiting, dehydration, lethargy) and complications (e.g., electrolyte imbalance, hypoglycemia, shock, sepsis) between Group 1 and Group 2. 4.Proportion of co-morbid illnesses such as pneumonia, sepsis, anemia, or tuberculosis, in Group 1 and Group 2, and their association with hospital stay and adverse outcomes. 5.Relationship between median duration of hospital stay with anthropometric indicators. 6.Proportion of children requiring intensive care support (ICU admission or advanced life support) and mortality between Group 1 and Group 2. Timepoint: 1 week—

Countries

India

Contacts

Public ContactDr Raghvendra Singh

Maulana Azad Medical College and Lok Nayak Hospital

drraghvendrasingh@gmail.com9968604426

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026