Comparison of the efficacy of nebulized magnesium sulphate versus dexamethasone in preventing post-operative sore throat after general anaesthesia

Comparison of the efficacy of nebulized magnesium sulphate versus dexamethasone in preventing post-operative sore throat following endotracheal intubation in patients undergoing laparoscopic surgeries- A double-blinded, randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/09/094028

Enrollment

Registered

2025-09-01

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Magnesium sulphate: Magnesium sulphate (50% W/V 2mL) with 3mL normal saline for nebulization 30 minutes before induction of anaesthesia in the preoperative receiving room Control Interv

Eligibility

Inclusion criteria

Inclusion criteria: Patients providing written informed consent Adults aged 18 to 60 years ASA Physical Status I or II Elective laparoscopic abdominal surgeries under general anaesthesia with endotracheal intubation

Exclusion criteria

Exclusion criteria: Pre existing sore throat, upper respiratory tract infection (URTI), or vocal cord pathology Anticipated difficult airway

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of nebulized magnesium sulphate versus dexamethasone in preventing post-operative sore throat (POST)Timepoint: 0-24 hours	—

Secondary

Measure	Time frame
To assess the incidence of associated post-operative nausea, vomiting (PONV) in both groups To evaluate the changes in haemodynamic profile in both groups Timepoint: 0-24 hours 0-120 minutes	—

Countries

India

Contacts

Public ContactDr Sunetra Sunder

Sri Manakula Vinayagar Medical College Kalitheerthalkuppam Madagadipet Puducherry

lazarus.suneeth@gmail.com9894332543

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026