Health Condition 1: E550- Rickets, active
Conditions
Interventions
Intervention1: Depot Oral cholecalciferol: Depot dose of 60000 IU oral cholecalciferol fortnightly (after every 2 weeks) for 5 doses in older children till 8 weeks and 3 doses fortnightly in infants t
Sponsors
Department of Paediatrics
Eligibility
Inclusion criteria
Inclusion criteria: Children aged 3 to 59 months Born at term more than equal to 37 weeks of gestation). Clinical features of rickets (skeletal or extraskeletal) with serum 25 hydroxy vitamin D less than 20 ng/mL
Exclusion criteria
Exclusion criteria: Chronic Kidney Disease , tubulopathies, or known kidney disorders Non Nutritional Rickets, such as rickets due to genetic disorders (e.g., hypophosphatemic rickets) or secondary to other metabolic conditions. Any chronic Illness that may affect calcium or vitamin D metabolism, such as liver disease, malabsorption syndromes, or parathyroid disorders. Use of Medications known to interfere with calcium or vitamin D metabolism (e.g., corticosteroids, anticonvulsants, glucocorticoids) in last three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Mean Urinary calcium: creatinine excretion in children following depot dose of oral cholecalciferolTimepoint: At baseline and 2 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1 Association of urine calcium excretion with baseline serum calcium & 25 hydroxy vitamin D levels, dietary calcium intake, renal function 2 Resolution of hypercalciuria in children with raised urinary calcium 3To evaluate the effect of cumulative cholecalciferol doses on urine calcium excretion.Timepoint: baseline 2 weeks & 12 weeks | — |
Countries
India
Contacts
Public ContactAashima Dabas
Maulana Azad Medical College
Outcome results
None listed