Health Condition 1: D509- Iron deficiency anemia, unspecified
Conditions
Interventions
Intervention1: Ferrous Sulphate at 6mg/kg: Ferrous sulphate syrup at 6mg/kg/day as a single dose for 12 weeks.
Control Intervention1: Ferrous sulphate at 3mg/kg: Ferrous sulphate syrup at 3mg/kg/day a
Sponsors
Intramural Research Grant, University College of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: All children with moderate and severe anemia AND underlying iron deficiency will be included. Moderate anemia defined as Hb- 7-9.4g per dl in children aged 3 months-23 months and Hb-7-9.9 g per dl in children aged 24 months-59 months. Severe anemia will be defined as Hb-less than 7g per dl for all children. Iron deficiency defined with peripheral blood smear suggestive of microcytic hypochromic picture AND low mean corpuscular volume (MCV) (upto 2 year less than 70 fl and 2 to 5 year less than 70 plus age in years AND serum ferritin less than 12 mcg per L in the absence of infection and less than 30 mcg per L in the presence of infection
Exclusion criteria
Exclusion criteria: 1. Children with other causes of anemia - vitamin-B12 deficiency, folic acid deficiency, dimorphic or megaloblastic anemia 2. Apparent non-nutritional etiology of anemia (obvious bleeding, chronic hemolytic anemia, malignancies) 3.Those who have received iron during last 2 weeks 4.Children who received blood/packed cell transfusion within last 3 months 5.Children with known or suspected chronic illness (chronic kidney disease, chronic liver disease, congenital heart disease, chronic infection)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of non-anemic children at 12 weeks of therapyTimepoint: 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in Hemoglobin after therapyTimepoint: 2, 8, 12 weeks;Serum ferritin levelTimepoint: 12 weeks;Proportion of participants compliant to oral therapyTimepoint: 1,2,4,8,12 weeks;Adverse effects experiencedTimepoint: 1,2,4,8,12 weeks;Proportion of non anemic childrenTimepoint: 8 weeks | — |
Countries
India
Contacts
Public ContactDr Anshu Chandra
Department of Pediatrics, UCMS and GTB Hospital
Outcome results
None listed