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Study on Body Chemicals and Root Changes During Backward Tooth Movement Using Different Braces Methods

Analysis of Interleukin-1 Receptor Antagonist Levels and Orthodontic Root Resorption During Retraction with Nickel Titanium Closed Coil Springs and Active Tiebacks: A Prospective Cohort Study - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/08/093875
Enrollment
10
Registered
2025-08-29
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K089- Disorder of teeth and supporting structures, unspecified

Interventions

Intervention1: Nickel Titanium Closed Coil Spring: Retraction of teeth using Nickel-Titanium (NiTi) Closed Coil Springs with expected duration of 1 year Intervention2: Nil: Nil Control Intervention1:

Sponsors

MES Dental College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with complete dentition and Angle?s Class I Bimaxillary protrusion Patients in the age group of 18 to 25 years Patients should have no radiographic sign of root resorption Patients should have healthy gingival and periodontal status

Exclusion criteria

Exclusion criteria: Missing molars or any anterior teeth Previous history of ortho treatment Erupted or unerupted supernumeraries in the maxillary anterior segment Impacted canines, Endodontically treated teeth Upper anterior crowding greater than or equal to 4mm Periodontitis

Design outcomes

Primary

MeasureTime frame
To evaluate the correlation between changes in interleukin-1 receptor antagonist (IL-1RA) levels in gingival crevicular fluid (GCF) and the severity of orthodontic root resorption (ORR) in patients undergoing space closure.Timepoint: T0 Before treatment T1 6 months after start of treatment T2 End of space closure—

Secondary

MeasureTime frame
To compare the differences in duration of retraction under two orthodontic mechanics with NiTi closed coil springs and active tiebacksTimepoint: T0 Before treatment T1 6 months after start of treatment T2 End of space closure—

Countries

India

Contacts

Public ContactSreelakshmi V

MES Dental College and Hospital

shaloobdr@gmail.com9746277277

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026