Clinical trial for comparing the effectiveness of nebulized nitroglycerin in patients with right heart failure with severe pulmonary artery hypertension vs placebo with nebulized normal saline.

Effectiveness of nebulized nitroglycerine in patients with right heart failure with severe pulmonary artery hypertension - A prospective,randomized, placebo controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/093843

Enrollment

Registered

2025-08-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I279- Pulmonary heart disease, unspecified

Interventions

Intervention1: Use of nebulised nitroglycerin in patients presenting with shortness of breath secondary to right heart failure: The intervention group will receive nebulized nitroglycerin administered

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients who are confirmed cases of right heart failure secondary to severe PAH presenting to emergency department with severe SOB. 2. Patients who have provided with written consent after explaining the intervention 3. Patients with SBP above 100 mmHg.

Exclusion criteria

Exclusion criteria: 1.known allergies to nitroglycerin 2.hypotension , left heart failure , severe ms 3.ACS , ARDS , severe COPD 4.pregnancy /lactation 5. Inability to provide consent 6 .known methemaoglobinemia

Design outcomes

Primary

Measure	Time frame
To evaluate the effectiveness and safety of nebulized nitroglycerine as an adjunctive therapy for managing shortness of breath secondary to severe PAH in right heart failure patients by measuring improvement in dyspnea score.. Timepoint: Outcomes are measured at baseline after giving 3rd dose of nebulization , after 1 and half hour	—

Secondary

Measure	Time frame
To compare vitals , blood gases , lactates , shock index To compare time on ventilator Mortality To compare echo findingsTimepoint: All the Outcomes except time on ventilator & mortality are measured at baseline after 3rd dose of nebulisation after 1 & half hour Time on ventilator & mortality is measured at discharge - with in 4 weeks	—

Countries

India

Contacts

Public ContactDr.Bala Ajay pavan Kumar reddy Kasu

Nizams institute of medical sciences

ashimanims@gmail.com9848248663

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026