Effect of different anti-oxidants in reducing tooth discoloration caused by silver diamine fluoride in primary molars

Comparative evaluation of the effect of different anti-oxidants in reducing tooth discoloration caused by 38 percent silver diamine fluoride in primary molars- a randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/093836

Enrollment

Registered

2025-08-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Alpha Lipoic acid: Alpha-lipoic acid (ALA) is a potent antioxidant with the presence of 2 thiol groups. Studies have found that it reduces discoloration caused by 38 percent SDF.Apply t

Eligibility

Inclusion criteria

Inclusion criteria: The study will include healthy children aged 3 to 8 years with a Frankl behavior rating of 3 or 4. Selected teeth were primary molars presenting with occlusal carious lesions having an ICDAS score of 3, 4, or 5, with radiographic evidence of sound dentin. Written informed consent was obtained from the parent prior to participation.

Exclusion criteria

Exclusion criteria: The exclusion criteria will comprise medically compromised patients, those with thyroid gland disorders, individuals with a known history of allergy to silver, and highly uncooperative patients.

Design outcomes

Primary

Measure	Time frame
To evaluate and compare the effectiveness of anti-oxidants ALA and GSH with KI in reducing discoloration caused by 38% SDF in carious primary molars.Timepoint: 4 weeks	—

Secondary

Measure	Time frame
To assess if the reduction in discoloration is acceptable by parents.Timepoint: 1 week;To evaluate the palatability of ALA, GSH & KI after application of 38 percent SDF.Timepoint: 1 week	—

Countries

India

Contacts

Public ContactDr Gagandeep Lamba

Ranjeet Deshmukh Dental College and Research centre

drgagandeeplamba@gmail.com8983184861

Outcome results