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Evaluating the Benefits of i-PRF in Gum Disease Treatment for Smokers and Non-Smokers

Comparative evaluation of the efficacy of subgingival application of i-PRF as adjunctive therapy to SRP in treatment of smoker versus non-smoker patients with Periodontitis: A split-mouth, randomized controlled clinical trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/093827
Enrollment
40
Registered
2025-08-28
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Injectable Platelet Rich Fibrin (i-PRF): i-PRF was prepared by centrifuging 10 ml of venous blood at 700 rpm for 3 minutes without anticoagulant. Control Intervention1: Placebo: Distill

Sponsors

Dr. Neha Singh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria included greater than or equal to 20 teeth, greater than or equal to contralateral sites with probing depth 5 to 6 mm and CAL less than or equal to 5 mm, and absence of plaque-retentive factors.

Exclusion criteria

Exclusion criteria: Exclusion criteria included systemic disease, recent periodontal therapy or antibiotics, pregnancy or lactation, or need for periodontal surgery.

Design outcomes

Primary

MeasureTime frame
Reduction in probing pocket depth (PPD) Gain in clinical attachment level (CAL)Timepoint: Baseline (prior to intervention) 1 month 3 months 6 months—

Secondary

MeasureTime frame
To assess changes in Plaque Index (Silness and L?e, 1964), Gingival Index (L?e and Silness, 1963), and Gingival Bleeding Index (Ainamo & Bay, 1975) in smokers and non-smokers with periodontitis.Timepoint: Baseline (prior to intervention) 1 month 3 months 6 months—

Countries

India

Contacts

Public ContactDr Neha Singh

Sudha Rustagi College of Dental science and research

drmeenu2005@gmail.com9871044433

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026