To compare the effects of nebulisation with lignocaine vs ropivacaine vs levobupivacaine to check the change in hemodynamic parameters during endotracheal intubation in patients undergoing general anaesthesia

The effects of nebulisation with 2 percent lignocaine vs 0.75 percent ropivacaine vs 0.5 percent levobupivacaine for attenuation of pressor response during direct laryngoscopy and endotracheal intubation in patients undergoing general anaesthesia - nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/093817

Enrollment

Registered

2025-08-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nebulisation using nebuliser circuit preoperatively: To nebulise preoperatively using 2% lignocaine vs 0.75% ropivacaine vs 0.5% levobupivacaine preoperatively - 10 ml each drug using n

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I & II Gender: Male/Female Elective surgeries under balanced general anesthesia requiring direct laryngoscopy and endotracheal intubation

Exclusion criteria

Exclusion criteria: Emergency surgeries Pregnant patients Patients with allergies to any study drug Patients with anticipated difficult airways Patients with moderate-severe cardiovascular, respiratory, renal, or hepatic impairment

Design outcomes

Primary

Measure	Time frame
Changes in heart rate from baseline at specified intervals Changes in systolic and diastolic blood pressure from baseline Changes in mean arterial pressure from baselineTimepoint: T0 (Baseline) T1 (Pre-nebulization) T2 (Post-nebulization) T3 (Pre-medication) T4 (post-premedication/induction) T5 (1 min post-intubation) T6 (3 min post-intubation) T7 (5 min post-intubation) T8 (10 min post-intubation) T9 (every 10 min interval throughout the duration of OT) Tp1 (1 min post-extubation) Tp2 (3 min post-extubation) Tp3 (5 min post-extubation) Tp4 (10 min post-extubation)	—

Measure

Time frame

Changes in heart rate from baseline at specified intervals Changes in systolic and diastolic blood pressure from baseline Changes in mean arterial pressure from baselineTimepoint: T0 (Baseline) T1 (Pre-nebulization) T2 (Post-nebulization) T3 (Pre-medication) T4 (post-premedication/induction) T5 (1 min post-intubation) T6 (3 min post-intubation) T7 (5 min post-intubation) T8 (10 min post-intubation) T9 (every 10 min interval throughout the duration of OT) Tp1 (1 min post-extubation) Tp2 (3 min post-extubation) Tp3 (5 min post-extubation) Tp4 (10 min post-extubation)

—

Secondary

Measure	Time frame
Incidence and severity of post-extubation cough (4-point scale) Incidence and severity of post-extubation sore throat (4-point scale) Occurrence of adverse events or complicationsTimepoint: PERI-EXTUBATION COUGH ASSESSMENT Time Cough Grade (0-3) 0 min 5 min 30 min POST-OPERATIVE SORE THROAT (POST) ASSESSMENT Time POST Grade (0-3) 30 min 3 hours 6 hours 12 hours 24 hours	—

Countries

India

Contacts

Public ContactDevyani Arora

Adesh Institute of medical sciences and research , Bathinda

drmmprao@gmail.com8699943250

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026