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Efficacy of oral tablet pentoxifylline along with injection of triamcinolone and hyaluronidase in oral cavity compared with injection of triamcinolone and hyaluronidase in oral cavity in management of decreased mouth opening

Comparison between Oral Pentoxifylline and Intralesional Injection Triamcinolone Hyaluronidase vs Intralesional Injection Triamcinolone + Hyaluronidase in Management of Oral Submucous Fibrosis. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/093811
Enrollment
60
Registered
2025-08-28
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K135- Oral submucous fibrosis

Interventions

Intervention1: Oral pentoxifylline along with intralesional injection triamcinolone and hyaluronidase in management of oral submucosal fibrosis: Half of the patients with oral submucosal fibrosis(acco

Sponsors

GMERS Hospital Gotri
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients clinically confirmed with oral submucosal fibrosis who have not undergone any previous treatment for the same.

Exclusion criteria

Exclusion criteria: Congenital disease. Pregnant and lactating woman. Medical history of cardiovascular, gastrointestinal, nephrological and metabolic disorders. Patients with coexisting orofacial disorders(including trauma)other than oral submucosal fibrosis that can interfere the study. Patients with oral cancer

Design outcomes

Primary

MeasureTime frame
Therapeutic efficacy of Oral Pentoxifylline with Intralesional Injection Triamcinolone and Hyaluronidase compared With Intralesional injection Triamcinolone and Hyaluronidase alone over 4 weeks in the treatment of submucosal fibrosis. Assessment by Khanna and Andrade Classification of Submucosal fibrosisTimepoint: 4 Weeks—

Secondary

MeasureTime frame
Tobacco Chewing duration & stage of oral sub mucosal fibrosis.Timepoint: 4 Weeks—

Countries

India

Contacts

Public ContactDr Aishwarya Chauhan Bhimji

GMERS Medical College and Hospital, Gotri

vishala_pandya@yahoo.com9824040485

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026