Health Condition 1: I00-I99- Diseases of the circulatory system Health Condition 2: I70-I79- Diseases of arteries, arterioles and capillaries
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Department Of Health Research (DHR-ICMR)
Eligibility
Inclusion criteria
Inclusion criteria: For cases 1. Patients diagnosed with CAD as per clinician advise 2. Age not less than 18 years 3. Given informed consent For Control 1. Age not less than 18 years, and age and sex matched with case groups 2. Negative angiogram or cases with no history of CAD, may be taken for control cases 3. Belong to North India (by descent) 4. Have epidemiologically similar data to the patients 5. Given informed consent
Exclusion criteria
Exclusion criteria: For Cases 1. Acute or chronic infection 2. Pregnancy 3. Malignancy 4. Autoimmune diseases 5. Mental illnesses 6. Age less than 18 years 7. Declined to give informed consent For Control 1. Are suffering from any other communicable or chronic disease such as AIDS, tuberculosis, hepatitis, etc. 2. Any history CAD 3. Pregnancy 4. Malignancy 5. Mental illnesses 6. Alcoholic, smokers and tobacco consumers 7. Age less than 18 years 8. Autoimmune diseases 9. Declined to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The anticipated outcomes is to find relationship between genetic polymorphisms in various candidate genes on the development and progression of CAD. Also to establish correlations between the genotypes of candidate genes and various cardiac function tests in CAD patients. The research will also yield statistical data regarding the polymorphisms of these candidate genes in the context of CAD, thereby contributing to the understanding of their potential as biomarkers for the disease.Timepoint: 36 months | — |
Secondary
| Measure | Time frame |
|---|---|
| ii. The results obtained from this study would help in the assessment of role of genetic polymorphism in Lipoprotein A gene in development & progression of CAD in patients of kumaon region.Timepoint: 30 months;iii. The results obtained from this study would help in the assessment of role of genetic polymorphism in Lectin like oxidized-LDL receptor-1 (LOX1) gene in development & progression of CAD in patients of kumaon region.Timepoint: 30 months;iv. The results obtained from this study would help in the assessment of role of genetic polymorphism in Proprotein convertase subtilisin kexin type 9 (PCSK9) gene in development & progression of CAD in patients of kumaon regionTimepoint: 30 months;v. The results obtained from this study would help in the assessment of role of genetic polymorphism in Endothelial Nitric Oxide Synthase (eNOS) gene in development & progression of CAD in patients of kumaon region.Timepoint: 30 months;vi. It would help to evaluate the correlation of above candidate genes genotype with various cardiac function tests in CAD patients.Timepoint: 30 months;vii. Statistical information will be obtained from this study regarding above candidate genes polymorphism in CAD patients.Timepoint: 30 months;viii. This study will help in evaluation the role of above candidate genes as a biomarker in CAD.Timepoint: 30 months;ix. The database from this study will help in planning future research in this field from Kumaon region of Uttarakhand.Timepoint: 30 months | — |
Countries
India
Contacts
Public ContactSomesh Mehra
Multidisciplinary Research Unit (MRU), Government Medical College Haldwani
Outcome results
None listed