Assessment of reversal time characteristics using full dose with two step administration of Neostigmine for antagonizing Atracurium induced moderate block using neuromuscular monitor ?Double blinded randomized control trial

Assessment of reversal time characteristics using full dose with two step administration of Neostigmine for antagonizing Atracurium induced moderate block using neuromuscular monitor .A Double blinded randomized control trial - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/093752

Enrollment

Registered

2025-08-27

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Assessment of reversal time characteristics using full dose with two step administration of Neostigmine for antagonizing Atracurium induced moderate block using neuromuscular monitor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patient belonging to ASA 1 and 2 2.Patient posted for surgeries under general anaesthesia in PIMS 3.BMI -18 to 35 kg/m2. Surgeries lasting for less than 2 hours

Exclusion criteria

Exclusion criteria: )Known allergy to anaesthetic drugs 2)Neuromuscular disease 3)Renal disorders ( serum creatinine > 1.8mg/dl) 4)Liver disorders ( liver function tests > 50% of normal value ) 5) Surgical position that prevent access to neuromuscular monitoring

Design outcomes

Primary

Measure	Time frame
To measure the effect of two step administration of neostigime after emergence of TOFc of 3 in reducing the reversal time of atracurium induced moderate block in patient undergoing general anaesthesia using inhalational anaesthesia as compared to full dose administration. Timepoint: Assessed intraoperatively and postoperatively 1hour(surgeries not more than approximately 2hours ).	—

Secondary

Measure	Time frame
1. To note the incidence of residual neuromuscular blockade postoperatively 2.To document the side effects of neostigmineTimepoint: Assessed intraoperatively & postoperatively 1hour(surgeries not more than approximately 2hours ). Assessed intraoperatively , postoperative period at baseline, 5 minutes, 10 minutes,15 minutes,20 minutes, 25 minutes, 30 minutes, 35 minutes, 40 minutes, 45 minutes, 50 minutes,55 minutes,60 minutes	—

Measure

Time frame

1. To note the incidence of residual neuromuscular blockade postoperatively 2.To document the side effects of neostigmineTimepoint: Assessed intraoperatively & postoperatively 1hour(surgeries not more than approximately 2hours ). Assessed intraoperatively , postoperative period at baseline, 5 minutes, 10 minutes,15 minutes,20 minutes, 25 minutes, 30 minutes, 35 minutes, 40 minutes, 45 minutes, 50 minutes,55 minutes,60 minutes

—

Countries

India

Contacts

Public ContactMahalakshmi M

Pondicherry Institute of Medical sciences

drmvvidya@gmail.com9585550838

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026