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Comparison of propofol and a combination of propofol-ketamine as sedation drugs for their effect on lung function in children undergoing magnetic resonance imaging procedures

Impact of Propofol vs Propofol-ketamine sedative regimen on lung atelectasis and diaphragm function in children undergoing magnetic resonance imaging: A Randomized Clinical Trial. - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/093722
Enrollment
150
Registered
2025-08-26
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G939- Disorder of brain, unspecified Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Propofol-Ketamine Group: Participants will receive 0.2 mL/kg of 0.5% propofol (mixture of 1% propofol and 0.9% saline) and 1 mg/kg of diluted ketamine in 0.9% saline (total 2 mL), follo

Sponsors

Shibani Padhy
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I to II Elective MRI Under Deep Sedation

Exclusion criteria

Exclusion criteria: 1. History of thoracic surgery 2. Associated pulmonary pathology eg. atelectasis, pneumonia, pneumothorax, or pleural effusion based on preoperative chest roentgenogram or Ultrasound and CT chest when available 3.Current respiratory infection with fever greter than 38?C, purulent cough, yellowish nose discharge, or wheezing sound, 4. Airway abnormality 5. Allergy or contraindications for the study drugs 6. Duration of MRI more than 2hours 7. Patient refusal 8. Inability to obtain a pre sedation baseline USG scan

Design outcomes

Primary

MeasureTime frame
The incidence of pulmonary atelectasis determined by lung ultrasonography. Atelectasis is defined as a juxtapleural consolidation score (C score) greater than 1 in more than one region, as determined by the lung ultrasound examinationTimepoint: From starting of anaesthesia to lung Ultrasound in the postsedation period.

Secondary

MeasureTime frame
1. Total lung score 2. Diaphragm excursion 3. Outcome:Respiratory complications 4. Outcome:Image quality 5. Adverse events during sedation and recovery 6. Recovery Profile(time to emergence and duration of PACU stay)Timepoint: 72hrs post MRI

Countries

India

Contacts

Public ContactShibani Padhy

Nizams Institute of medical sciences

drshibanipadhy@gmail.com8332921975

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026