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Effect of Nalbuphine on hemodynamics during laryngoscopy in general anaesthesia for ENT surgeries

EVALUATE OF HAEMODYNAMIC RESPONSE OF INTRAVENOUS NALBUPHINE DURING LARYNGOSCOPY AND TRACHEAL INTUBATION IN SURGERIES OF EAR NOSE THORAT (ENT) DONE UNDER GENERAL ANAESTHESIA - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/093678
Enrollment
90
Registered
2025-08-26
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nalbuphine: Intravenous Nalbuphine 150 microgram per Kg will be given for reducing anxiety during induction of anaesthesia with orotracheal intubation. Assessment will be done in 1 hour

Sponsors

Datta Meghe Institute of Higher Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of elective ENT procedures under GA. Patients weighing between 40 to 80kg. Patients belonging to ASA grade I and II. Patients with anticipated difficult airways according to LEMON criteria.

Exclusion criteria

Exclusion criteria: Patients with known drug allergy. Patients of emergency surgeries. Patients belonging to ASA grade III or higher. Patients with uncontrolled systemic disease. Pregnant or lactating females.

Design outcomes

Primary

MeasureTime frame
Nalbuphine IV (150mcg/kg) injected before induction of elective surgeries in ENT to be done under general anaesthesia will effectively attenuate the hemodynamic stress response of orotracheal intubationTimepoint: T0-Baseline premedication vitals,T1-3 minutes after administration of Nalbuphine,T2-1 minute after induction and intubation,T3-3 minutes after intubatin,T4-5 minutes after intubation,T5-10 minutes after intubation.

Secondary

MeasureTime frame
NilTimepoint: NA

Countries

India

Contacts

Public ContactDhruv Shah

Datta Meghe Institute of Higher Education and Research

jayashree_sen@rediffmail.com9813061192

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026