Pain relief after gallbladder keyhole surgery: comparing a new nerve block (M-TAPA) with routine local injection and pain medicines

Comparison of Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) versus Port- Site local Infiltration and Opioid based Analgesia in Laparoscopic Cholecystectomy: A Prospective, Randomized Control Study - M-TAPA

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/093674

Enrollment

113

Registered

2025-08-26

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis

Interventions

Intervention1: Modified Thoracoabdominal Nerve Block through Perichondrial Approach (M-TAPA): Administered after induction of general anesthesia, before surgical incision. Bilateral injections under u

Eligibility

Inclusion criteria

Inclusion criteria: ASA Physical Status 1,2,3 Elective laparoscopic cholecystectomy under general anesthesia Patients who provide written informed consent

Exclusion criteria

Exclusion criteria: Patient refusal ASA 4 or higher Emergency or open cholecystectomy Coagulopathy or anticoagulant therapy Local infection at block site Allergy to local anesthetics Chronic opioid use or chronic pain disorder Severe hepatic or renal impairment

Design outcomes

Primary

Measure	Time frame
Postoperative pain scores using Numeric Rating Scale (NRS, 0?10)Timepoint: At immediate post operative period or 0 hours, 2 hours, 4 hours, 8 hours, 12 hours and 24 hours post operatively.	—

Secondary

Measure	Time frame
Total opioid consumption in 24 hours (IV tramadol/fentanyl equivalent) intraoperative and postopertiveTimepoint: cumulative intraoperative and postoperative;Hemodynamic response to surgical stimulus (MAP and HR)Timepoint: At trocar insertion, 5, 10, 15 min after pneumoperitoneum, and at extubation;Hemodynamics in postoperative period (MAP and HR)Timepoint: At 1, 2, 4, 8, 12, and 24 hours postoperatively ;Incidence of postoperative nausea and vomiting (PONV)Timepoint: 0?24 hours postoperatively;Patient satisfaction score (Likert scale)Timepoint: At 24 hours	—

Measure

Time frame

Total opioid consumption in 24 hours (IV tramadol/fentanyl equivalent) intraoperative and postopertiveTimepoint: cumulative intraoperative and postoperative;Hemodynamic response to surgical stimulus (MAP and HR)Timepoint: At trocar insertion, 5, 10, 15 min after pneumoperitoneum, and at extubation;Hemodynamics in postoperative period (MAP and HR)Timepoint: At 1, 2, 4, 8, 12, and 24 hours postoperatively ;Incidence of postoperative nausea and vomiting (PONV)Timepoint: 0?24 hours postoperatively;Patient satisfaction score (Likert scale)Timepoint: At 24 hours

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Countries

India

Contacts

Public ContactDegutla Karthik Chary

Kd95.work@gmail.com8328535344

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026