Health Condition 1: J15- Bacterial pneumonia, not elsewhereclassified
Conditions
Interventions
Intervention1: Group BI (Both Bronchoscopic instillation and Intravenous antibiotic group): Group BI (Both Bronchoscopic instillation and Intravenous antibiotic group) will receive the prescribed dose
Sponsors
ALL INDIA INSTITUTE OF MEDICAL SCIENCES,RISHIKESH
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients both male and female aged more than 18 years 2.Diagnosed as ventilator associated pneumonia with a CPIS score of more than 6 3.Culture positive for organisms with intermediate sensitivity to Colistin 4. Intubated on Ventilator support
Exclusion criteria
Exclusion criteria: 1.Patients/next of Kin refusal to consent. 2.Patients with Multiple Organ Dysfunction Syndrome (MODS),septic shock at the beginning of the study. 3.Patients with a P/F (PaO2/FiO2) ratio below 100 4.Patients with severe COPD more than Grade GOLD 3E 5.Patients with recent myocardial infarction within 6 months or Heart failure with reduced Ejection Fraction (HFrEF) with Ejection Fraction (EF) less than 40 percentage 6.Immunodeficient patients 7.History of allergy to Colistin 8.Patients with infections resistant to Colistin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare ventilator free daysTimepoint: till day 28 | — |
Secondary
| Measure | Time frame |
|---|---|
| CPIS scoreTimepoint: Day 7;CPIS score less than 6Timepoint: till day 7;To compare the mortality between the two groupsTimepoint: within 28 days;To compare the length of ICU-stay between the two groupsTimepoint: till day 28;To compare the length of hospital-stay between the two groupsTimepoint: till day 28;adverse effectsTimepoint: till 3 days | — |
Countries
India
Contacts
Public ContactDr Deepak Singla
AIIMS RISHIKESH
Outcome results
None listed