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Assessment of efficacy of Eadyn in predicting rise in blood pressure using simple leg raise in septic shock patient

Assessment of pressure responsiveness with Eadyn using passive leg raise in adult patient with sepsis - A Prospective Observational study - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/08/093621
Enrollment
86
Registered
2025-08-25
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B968- Other specified bacterial agents as the cause of diseases classified elsewhere Health Condition 2: B968- Other specified bacterial agents as the cause of diseases classified elsewhere

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil Intervention5: Nil: Nil

Sponsors

JIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adults with preserved spontaneous respiratory efforts aged between 18 to 65 years with sepsis requiring vasopressor therapy to maintain MAP of more than or equal 65 mmHg after initial resuscitation or capillary refill time more than 3 seconds or lactate levels more than 2mmol per litre or urine output less than 0.5ml per kg per hr for at least 2hours. Sequential organ failure assessment score more than 2. Patients with arterial catheter and central venous line in situ.

Exclusion criteria

Exclusion criteria: Pregnancy Patients with Arrhythmias, increased intracranial hypertension, head trauma, pain or agitation Right heart failure, defined here as evidence of abnormal RV structure or function with clinical signs of right heart failure, including edema in both legs, hepatomegaly With suspected increased intra-abdominal pressure Ongoing neuromuscular blockade Vasoactive Inotropic Score(VIS) 20 With peripheral vascular disease Burns involving extremities.

Design outcomes

Primary

MeasureTime frame
To evaluate the ability of Eadyn-guided dynamic assessment in predicting pressure responsiveness with passive leg raise among critically ill adults with sepsis.Timepoint: on admission to critical care unit—

Secondary

MeasureTime frame
To correlate the Eadyn derived from cardiac output monitor alone and the Eadyn derived with echocardiography and cardiac output monitor in responders and non-responders. Timepoint: on admission to critical care unit;To compare velocity time integral (VTI) response to PLR and continuous cardiac output monitor stroke volume response between the responders and non-respondersTimepoint: on admission to critical care unit—

Countries

India

Contacts

Public ContactKANDASWAMY N

JIPMER

kandaraghav@gmail.com9952082858

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026