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Comparison of effects of Amisulpride and Dexamethasone vs Ondansetron and Dexamethasone on post-operative nausea and vomiting in patients of middle ear surgery- A randomised, double blinded study

Comparison of effects of Amisulpride and Dexamethasone vs Ondansetron and Dexamethasone on post-operative nausea and vomiting in patients of middle ear surgery- A randomised, double blinded study - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/093603
Enrollment
60
Registered
2025-08-25
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Amisulpride + Dexamethasone: Patients of this group will receive injection Dexamethasone 8mg (2 ml) and Amisulpride 5 mg (2 ml) I/V just before the induction of anesthesia, and normal s

Sponsors

Sharda Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for middle ear surgery under general anaesthesia. 2. Patients aged 18-60 years 3. ASA Class I and II. 4. Both genders

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
To compare the effects of amisulpride and dexamethasone vs ondansetron and dexamethasone on incidence of post-operative nausea and vomiting in patients of middle ear surgery.Timepoint: 24 hours—

Secondary

MeasureTime frame
1. To compare PONV free period and requirement of rescue antiemetic in two groups during postoperative 24 hrs. 2. To compare the degree of post-operative sedation at various intervals in two groups.Timepoint: 24 hours—

Countries

India

Contacts

Public ContactDr Mahendra kumar

Sharda University

mahendra.kumar@sharda.ac.in8287188449

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026