To compare the efficacy of only Ketamine and Ketamine - Dexmedetomidine in reducing propofol dose for IV sedation in short gynaecological procedures

Efficacy of Ketamine versus Ketamine ? Dexmedetomidine on effect site concentration of propofol target controlled infusion in short gynaecological procedures ? Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/093580

Enrollment

Registered

2025-08-25

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Ketamine- Propofol: Patients receiving Ketamine at dose of 0.75 mg/kg bolus with Propofol TCI at baseline effect site concentration of 2.0 mcg/ml. The patient will be assessed every 3 m

Eligibility

Inclusion criteria

Inclusion criteria: Age 18 ? 60 years Female Gender Patients posted for elective short gynaecological procedures ASA Physical Status I to III

Exclusion criteria

Exclusion criteria: Refusal to give informed consent

Design outcomes

Primary

Measure	Time frame
To compare the Effect site concentration of propofol TCI with only ketamine and with ketamine dexmedetomidineTimepoint: Baseline, 3 minutes, 6 minutes, 9 minutes, 12 minutes, 15 minutes, 18 minutes, 21 minutes, 24 minutes, 27 minutes, 30 minutes	—

Secondary

Measure	Time frame
To assess the incidence of intraoperative airway events in both group To assess the hemodynamics during the procedure in both groups To assess the recovery time in both groupsTimepoint: 0-30 minutes	—

Countries

India

Contacts

Public ContactNithiyasree S

Sri Manakula Vinayagar Medical College Kalitheerthalkuppam Madagadipet Puducherry

ranjanrv2005@gmail.com9600823772

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026