Health Condition 1: H160- Corneal ulcer
Conditions
Interventions
Intervention1: Fungal ulcer treated with antifungas with 0.1% cyclosporine or 2% cyclosporine: In addition to conventional antifungal eye drops, 0.1% or 2% cyclosporine eye drops will be used as 4 tim
Sponsors
Aravind Eye Hospital
Francis I Proctor foundation
Eligibility
Inclusion criteria
Inclusion criteria: Smear or culture positive for fungal keratitis, of any size and Visual acuity of worse than 6/12 and better than 3/60
Exclusion criteria
Exclusion criteria: Impending perforation/perforation/endophthalmitis Evidence of acanthamoeba by stain/herpetic keratitis by history or exam/bacterial mixed infection History of corneal scar in the affected eye and best corrected visual acuity worse than 6/60 in other eye Bilateral ulcers Previous penetrating keratoplasty Known allergy to study medications (cyclosporine or preservative) Previous history of topical steroid/native medication use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Best corrected visual acuity at 3 months between the placebo and intervention groupsTimepoint: Best corrected visual acuity at 3 months between the placebo and intervention groups | — |
Secondary
| Measure | Time frame |
|---|---|
| Scar sizeTimepoint: 3 months;Corneal perforation and need for therapeutic keratoplastyTimepoint: 3 months | — |
Countries
India
Contacts
Public ContactJosephine Christy
Aravind Eye Hospital, Pondicherry, India
Outcome results
None listed