A comparative study between Dexmedetomidine and Esmolol in keeping heart rate and blood pressure stable during gall bladder surgery using laparoscopic method under general anesthesia.

A comparative evaluation between Dexmedetomidine and Esmolol for hemodynamic responses to pneumoperitoneum during laparoscopic cholecystectomy under general anesthesia in a tertiary care hospital in Sikkim- A double blinded randomized controlled study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/093471

Enrollment

Registered

2025-08-22

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K808- Other cholelithiasis

Interventions

Intervention1: A comparative evaluation between Dexmedetomidine and Esmolol for hemodynamic responses to pneumoperitoneum during laparoscopic cholecystectomy under general anesthesia.: Once incision i

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 & ASA 2

Exclusion criteria

Exclusion criteria: Refusal to participate ASA 3 & ASA 4

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of two study drugs, Dexmedetomidine and Esmolol in attenuating hemodynamic parameters (heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure and oxygen saturation) during pneumoperitoneum for patients undergoing laparoscopic cholecystectomy under general anesthesia.Timepoint: At the time of giving study drug then initiation of pneumoperitoneum and every 3 minutes after the pneumoperitoneum is established and for the first 15 minutes, then every 15 minutes for the first hour and every 30 minutes for the next 2 hours or until the pneumoperitoneum ends.	—

Measure

Time frame

To compare the efficacy of two study drugs, Dexmedetomidine and Esmolol in attenuating hemodynamic parameters (heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure and oxygen saturation) during pneumoperitoneum for patients undergoing laparoscopic cholecystectomy under general anesthesia.Timepoint: At the time of giving study drug then initiation of pneumoperitoneum and every 3 minutes after the pneumoperitoneum is established and for the first 15 minutes, then every 15 minutes for the first hour and every 30 minutes for the next 2 hours or until the pneumoperitoneum ends.

—

Secondary

Measure	Time frame
Using Dexmedetomidine will reduce the chances of using any additional analgesic use.Timepoint: During initiation of penumoperitoneum,every 3 minutes after the pneumoperitoneum is established and for the first 15 minutes, then every 15 minutes for the first hour and every 30 minutes for the next 2 hours or until the pneumoperitoneum ends.	—

Countries

India

Contacts

Public ContactDr Awantika Rai

Sikkim Manipal Institute of Medical Science

meyong.b@smims.edu.in9614389839

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026