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improvment in liver enzymes and symptoms in patients with cholestasis of pregnancy after ursodeoxycholic acid therapy

BIOCHEMICAL MILIEU IN INTRAHEPATIC CHOLESTASIS OF PREGNANCY AND ITS IMPROVEMENT WITH URSODEOXYCHOLIC ACID - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/093440
Enrollment
70
Registered
2025-08-21
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O266- Liver and biliary tract disordersin pregnancy, childbirth and the puerperium

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: URSODEOXYCHOLIC ACID: ursodeoxycholic acid with dose of 300 mg twice a day continue till delivery or until lft co

Sponsors

MLN MEDICAL COLLEGE ALLAHABAD
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Pregnant women in late 2nd (26-28 weeks) and 3rd trimester with Intrahepatic cholestasis of pregnancy.

Exclusion criteria

Exclusion criteria: 1.Preeclampsia, eclampsia 2.Acute fatty liver of pregnancy 3.Viral hepatitis (HAV, HBV, HCV, HEV). 4.Liver cirrhosis, tumors 5.Autoimmune liver disease. 6.Obstructive biliary disease. ? Known kidney diseases. ? Dermatoses of pregnancy- Gestational pemphigoid, pruritic and urticarial papules and plaques (PUPPP), atopic eruption of pregnancy i.e., eczema and prurigo. ? Impetigo herpetiformis- triggered by pregnancy

Design outcomes

Primary

MeasureTime frame
To establish the effect of ursodeoxycholic acid in the liver biochemical markers [Serum bile acid, Serum bilirubin, serum liver transaminases (ALT, AST), alkaline phosphatase] in Patients of IHCP.Timepoint: 1 week and 2weeks—

Secondary

MeasureTime frame
To assess the perinatal outcome after ursodeoxycholic acid therapy in IHCPTimepoint: 1 week & 2 weeks—

Countries

India

Contacts

Public ContactRUCHI PATEL

MLN MEDICAL COLLEGE ALLAHABAD

dhrndrsngh11@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026