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A Study to compare Intravenous Lignocaine versus Ketamine versus Normal saline on Post operative pain after Abdominal surgeries under General Anaesthesia at SMS Medical College, Jaipur.

A Randomised Controlled Study to Evaluate the Effect of Perioperative Intravenous Lignocaine versus Ketamine versus Normal Saline on Post Operative Pain after Abdominal Surgeries under General Anaesthesia at SMS Medical College, Jaipur. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/093418
Enrollment
126
Registered
2025-08-21
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Injection Lignocaine: Patient will receive inj lignocaine continuous infusion1.5mg/kg/hr at the rate of 5ml/hr for 1.5 hours Control Intervention1: Injection Ketamine: Patient will rece

Sponsors

Sawai Man Singh Medical college and hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients scheduled for abdominal surgeries under general anaesthesia. 2.Patient willing to give informed written consent. 3.American Society of Anaesthesiologist (ASA) physical status I and II. 4.Duration of surgery upto 120 minutes.

Exclusion criteria

Exclusion criteria: 1.Patient who is a part of any other study. 2.Pregnant or breastfeeding patients. 3.Obese 4.Chronic preoperative opioid use or substance abuse and history of chronic pain. 5.Allergy or contraindications to use of study medications such as cardiac, renal, hepatic disease, seizure or other neurological disorder. 6.Patients requiring postoperative mechanical ventilation.

Design outcomes

Primary

MeasureTime frame
1.To assess and compare the difference in time to first rescue analgesic administration in first 24 hours postoperatively among the groups. Timepoint: 1.To assess and compare the difference in time to first rescue analgesic administration in first 24 hours (1hr, 2hrs, 3hrs, 4hrs, 6hrs, 8hrs, 10hrs, 12hrs, 18hrs, 24hrs)postoperatively among the groups.—

Secondary

MeasureTime frame
1. To assess & compare the difference in mean rescue analgesic consumption in first 24 hours postoperatively among the groups 2.To assess & compare the difference in mean VAS scores in first 24 hours (1hr, 2hrs, 3hrs, 4hrs, 6hrs, 8hrs, 10hrs, 12hrs, 18hrs, 24hrs) postoperatively among the groups. 3.To assess & compare the difference in mean Ramsay Sedation Score in first 24 hours (1hr, 2hrs, 3hrs, 4hrs, 6hrs, 8hrs, 10hrs, 12hrs, 18hrs, 24hrs) postoperatively among the groups. 4.To assess & compare the change in Haemodynamic parameters (HEART RATE (bpm), SBP(mm hg), DBP(mm hg) & MAP (mm hg)) from baseline at different time intervals among the groups. 5.To assess & compare the difference in the proportion of cases with side effects ( like tinnitus, numbness, psychomotor disturbances, nausea, vomiting up to 24 hours among the groups. Timepoint: (1hr, 2hrs, 3hrs, 4hrs, 6hrs, 8hrs, 10hrs, 12hrs, 18hrs, 24hrs)—

Countries

India

Contacts

Public ContactDr Kanchan Chauhan

Sawai Man Singh Medical College and Hospital

drragu17@gmail.com9698070211

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026