Investigating the Effects of iTBS on Cognitive Function in People Recovering from Heroin Addiction

Investigating the Impact of Intermittent Theta Burst Stimulation (iTBS) on Neurocognition. A Comprehensive Examination of Cognitive Functions Post Treatment Efficacy in Heroin Dependent Individuals. A Single Blind Placebo Controlled Randomized Clinical Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/093417

Enrollment

150

Registered

2025-08-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F112- Opioid dependence

Interventions

Intervention1: Intermittent Theta Burst Stimulation (iTBS): The treatment intervention with stimulation intensity at 80 percent of resting motor threshold (RMT) will consist of bursts delivered at a f

Eligibility

Inclusion criteria

Inclusion criteria: Age range: 18 to 60 years. Any sexual orientation. Giving informed consent in writing. A DSM 5 (ICD-11) diagnosis of opioid (Heroin) use disorder. Tobacco dependence will be included. Basic education level of 8th and above. Individuals suffering from physical comorbidities like diabetes, HIV, HCV will be included. All participants will be right-handed as per Edinburgh Handedness inventory (1971)-Right Handedness

Exclusion criteria

Exclusion criteria: Individuals who suffer from co-occurring substance use disorders, excluding heroine. Individuals who have any kind of electrical or metallic intracranial implants. Women who are nursing or pregnant. Individuals with intellectual disability. Individuals suffering from any kind of neurological condition, such as multiple sclerosis, stroke, epilepsy, or encephalopathy. Individuals suffering from primary mood disorders or primary psychosis.

Design outcomes

Primary

Measure	Time frame
To evaluate the efficacy of Intermittent Theta Burst Stimulation (iTBS) in neurocognitive functions, by using a battery of standardized neuropsychological tests, including Raven?s Standard Progressive Matrices, HVLT Learning Test, the WCST-64, the Iowa Gambling Task, the Stroop Test, the Digit Symbol Substitution Test, and the Stop Signal Task.Timepoint: Baseline, T3 days, T90 days	—

Secondary

Measure	Time frame
To test saftey and tolerability of the iTBS treatment. To test iTBS treatment Efficacy in the reduction of craving. To test the levels of Bio Marker BDNF: Brain-Derived Neurotrophic Factor (BDNF).Timepoint: Baseline, T3 days, T90 days	—

Countries

India

Contacts

Public ContactDhruv Singh Bangar

Postgraduate Institute of Medical Education and Reserach

drdevenderrana@gmail.com9988059900

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026