A Study On Olanzapine and Amisulpride for reducing Nausea and Vomiting After Laparoscopic Gynecology Surgery

To Study the effect of olanzapine and amisulpride in post operative nausea and vomiting in laparoscopic gynecological surgeries -A randomized double-blind study - GYNOVA Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/093415

Enrollment

121

Registered

2025-08-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O94-O9A- Other obstetric conditions, not elsewhere classified

Interventions

Intervention1: Olanzapine: Tab olanzapine 10mg P/O 90 mins before inductionat the end of Surgery patients will be extubated and monitored for postoperative nausea and vomiting from 0 hours and Initial

Eligibility

Inclusion criteria

Inclusion criteria: Patients between age 20 to 50 years posted for elective laparoscopic gynecological surgeries requiring general anesthesia will be included

Exclusion criteria

Exclusion criteria: 1.Refusal to participate in the study 2.Pregnant or lactating female 3.Patient having cardiovascular/neurological condition 4.Patients on Antipsychotic medication 5.History of allergy to study drug

Design outcomes

Primary

Measure	Time frame
To monitor postoperative nausea and vomiting for 24 hrsTimepoint: Incidence of postoperative nausea and vomiting will be assessed at the following time points :0.5hr,1hr,1.30hr,2hr,4hr,6hr,8hr,12hr,18hr and 24hr	—

Secondary

Measure	Time frame
1.Time of rescue antiemetic 2.Total dose of rescue antiemetic. 3.Side effects if any.Timepoint: From end of surgery to 24 hrs	—

Countries

India

Contacts

Public ContactDr NithishT

IMS & SUM Hospital

dr.madhu.patro@gmail.com8072246307

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026