A clinical study to compare the effectiveness of dashang lepa and dhatura lepa in reducing symptoms such as pain , swelling and redness in patients with cellulitis (vranashopha)

A Comparative clinical study of Dashanga lepa and Dhatura lepa in the management of vranashopha (cellulitis). - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/093362

Enrollment

Registered

2025-08-20

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L031- Cellulitis and acute lymphangitisof other parts of limb

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age Range: Individuals aged between 12 and 60 years, inclusive. 2. Diagnosis: Clinically diagnosed cases of Vranashopha (Cellulitis) based on classical Ayurvedic and modern parameters. 3. Location of Lesion: Lesions must be located on the extremities (upper or lower limbs). 4. Size of Lesion: Patients with lesion size ranging from 5 cm to 15 cm in diameter (measured with measuring tape or scale). 5. Willingness and Compliance: Participants must be able and willing to attend regular follow-up visits as per study schedule (Days 0, 2, 4, 6). Must be willing to follow the treatment regimen, including local application of Lepa. 6. Informed Consent: Participants (or legal guardians for minors aged 12 17 years) must be willing and able to provide written informed consent in a language they understand

Exclusion criteria

Exclusion criteria: Septicemia: Patients presenting with septicemia or systemic signs of infection requiring emergency care. 2. Surgical Intervention Needed: Patients who require surgical debridement of the wound. 3. Uncontrolled Diabetes Mellitus: Patients with uncontrolled blood glucose levels or known cases of poorly managed diabetes. 4. Immunocompromised Status: Patients with HIV/AIDS or other immunosuppressive conditions. Patients currently undergoing immunosuppressive therapy. 5. Allergy or Hypersensitivity to Dhatura: Known hypersensitivity, allergy, or adverse reactions to Dhatura or any ingredients of the lepa. 6. Chronic or Complicated Ulcers/Wounds: Tubercular ulcers Venous ulcers Malignant ulcers Non-healing wounds (e.g., varicose ulcers) Kshatavrana (traumatic wounds) with complications such as fractures or marmaghat (vital organ injury) 7. Other Conditions: Known cases of Hepatitis B or Hepatitis C

Design outcomes

Primary

Measure	Time frame
Clinical efficacy of Dashang lepa vs Dhatura lepa in the management of Vranshopha ( cellulitis)Timepoint: Day 0 Baseline (before treatment starts) Day 2 First follow-up Day 4 Second follow-up Day 6 Final assessment (end of treatment period)	—

Secondary

Measure	Time frame
Overall clinical improvement and reduction in subjective and objective symptomsTimepoint: 0,2 ,4, 6 days;Hematological and biochemical changes and time to noticeable symptom relief in pain , swelling, redness and itching .Timepoint: 0 ,2 , 4 , 6 days;Safty , tolerability and adverse reaction of dashang and dhatura lepaTimepoint: 0, 2, 4, 6 days;Patient satisfaction / Compliance with subjective feedback regarding comfort ease of application and perceived improvement.Timepoint: 0, 2, 4, 6, days	—

Measure

Time frame

Overall clinical improvement and reduction in subjective and objective symptomsTimepoint: 0,2 ,4, 6 days;Hematological and biochemical changes and time to noticeable symptom relief in pain , swelling, redness and itching .Timepoint: 0 ,2 , 4 , 6 days;Safty , tolerability and adverse reaction of dashang and dhatura lepaTimepoint: 0, 2, 4, 6 days;Patient satisfaction / Compliance with subjective feedback regarding comfort ease of application and perceived improvement.Timepoint: 0, 2, 4, 6, days

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Countries

India

Contacts

Public ContactVd Vaibhav Hari Pagore

ASHVIN RURAL AYURVED COLLEGE AND HOSPITAL MANCHI HILL, SANGMNER

drkhandizod1964@gmail.com8975780848

Outcome results