Mechanistic trial of problem solving and behavioural activation for youth depression

Mechanistic trial of problem solving and behavioural activation for youth depression (METROPOLIS) - METROPOLIS

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/093354

Enrollment

714

Registered

2025-08-20

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Problem-Solving (PS): Brief Problem-Solving (PS) intervention delivered over 4â??5 sessions (approximately weekly) with a trained peer supporter (â??Saathiâ?), primarily in person, wit

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1) Aged 18 to 24 years. 2) Enrolled as a student (undergraduate or postgraduate) at specified campus locations in New Delhi. 3) Proficient in written and spoken English or Hindi, as needed to participate fully in study procedures. 4) Willing and able to provide informed consent to participate. 5)PHQ-9 total score of 10+.

Exclusion criteria

Exclusion criteria: Exclusion criteria: 1) Outside of the target age range. 2) Not enrolled as a student at one of the specified campus locations. 3) Unable to speak or write in English or Hindi as needed to participate fully in study procedures. 4) Unwilling or unable to provide informed consent. 5) Suicidal ideation (identified on PHQ-9) AND plan/intent/past attempt (identified on Columbia-Suicide Severity Rating Scale (CSSRS)).

Design outcomes

Primary

Measure	Time frame
Patient Health Questionnaire-9-item version (PHQ-9) (Kroenke, Spitzer & Williams, 2001)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months	—

Secondary

Measure	Time frame
Generalised Anxiety Disorder-7-item version (GAD-7) (Spitzer, Kroenke, Williams & LÃ¶we, 2006)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;WHO Disability Assessment Schedule Version 2.0 (WHODAS 2.0) (Uston et al., 2010)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Academic Behavioural Confidence scale (ABC) (Sander & Sanders, 2003)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Problem-Solving Inventory (20-item version, PSI-20) (Pretorius, et al., 2023)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Behavioural Activation for Depression Scale, Short Form (BADS-SF) (Manos, Kanter & Luo, 2011)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Environmental Reward Observation Scale (EROS) (Armento & Hopko, 2007)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;University of California Undergraduate Experience Survey (UCEUS) (Brint & Cantwell, 2010)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Adult Hope Scale (AHS) (Snyder et al., 1991)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Working Alliance Inventory - Short Revised (WAI-SR) (Hatcher & Gillaspy, 2006)Timepoint: 1) 6 Weeks ;Multiple Identity Minority Stress Scale (MIMSS) (Mathew et al., in preparation) (NB: to be tested as a moderator)Timepoint: 1) Baseline;Brief Daily Stressors Screening Tool (BDSST) (Scholten et al., 2020) (NB: to be tested as a moderator)Timepoint: 1) Baseline;EuroQol-5 Dimensions-5 Levels (EQ-5D-5L) (Herdman et al., 2011) (NB: to be used for economic evaluation)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Client Service Receipt Inventory (CSRI) â?? adapted (Nadkarni et al., 2024; PSSRU, 2025) (NB: to be used for economic evaluation)Timepoint: 1) Baseline 2) 12 Months;Cost of Receiving Treatment Questionnaire (CRTQ) (NB: to be used for economic evaluation)Timepoint: 1) 6 Weeks;Modified EDinburgh Adverse effects of Psychological Therapy (EDA	—

Measure

Time frame

Generalised Anxiety Disorder-7-item version (GAD-7) (Spitzer, Kroenke, Williams & LÃ¶we, 2006)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;WHO Disability Assessment Schedule Version 2.0 (WHODAS 2.0) (Uston et al., 2010)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Academic Behavioural Confidence scale (ABC) (Sander & Sanders, 2003)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Problem-Solving Inventory (20-item version, PSI-20) (Pretorius, et al., 2023)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Behavioural Activation for Depression Scale, Short Form (BADS-SF) (Manos, Kanter & Luo, 2011)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Environmental Reward Observation Scale (EROS) (Armento & Hopko, 2007)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;University of California Undergraduate Experience Survey (UCEUS) (Brint & Cantwell, 2010)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Adult Hope Scale (AHS) (Snyder et al., 1991)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Working Alliance Inventory - Short Revised (WAI-SR) (Hatcher & Gillaspy, 2006)Timepoint: 1) 6 Weeks ;Multiple Identity Minority Stress Scale (MIMSS) (Mathew et al., in preparation) (NB: to be tested as a moderator)Timepoint: 1) Baseline;Brief Daily Stressors Screening Tool (BDSST) (Scholten et al., 2020) (NB: to be tested as a moderator)Timepoint: 1) Baseline;EuroQol-5 Dimensions-5 Levels (EQ-5D-5L) (Herdman et al., 2011) (NB: to be used for economic evaluation)Timepoint: 1) Baseline 2) 6 Weeks 3) 6 Months 4) 12 Months;Client Service Receipt Inventory (CSRI) â?? adapted (Nadkarni et al., 2024; PSSRU, 2025) (NB: to be used for economic evaluation)Timepoint: 1) Baseline 2) 12 Months;Cost of Receiving Treatment Questionnaire (CRTQ) (NB: to be used for economic evaluation)Timepoint: 1) 6 Weeks;Modified EDinburgh Adverse effects of Psychological Therapy (EDA

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Countries

India

Contacts

Public ContactDr Pattie Gonsalves

Sangath

pattie.gonsalves@sangath.in9899419704

Outcome results