Health Condition 1: - Health Condition 2: K743- Primary biliary cirrhosis
Conditions
Interventions
Intervention1: Premedication: Premedication with intranasal ketamine 4mg/kg and dexmedetomidine 2microgram/kg once before upper GI endoscopy, duration will be around 60 seconds
Control Intervention1:
Sponsors
Investigator Dr Jasmin Bulbul
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients undergoing upper GI Endoscopy 2.parents agreeing to participate in study 3.Adequate NPO status
Exclusion criteria
Exclusion criteria: Inadequate NPO status Known allergy to given drugs Vascular disorders like NCPF ,EHPVO, Budd chiari syndrome Massive ascitis H/O upper airway obstruction, severe respiratory disease, or congenital heart disease Patients with H/O developmental delay or behavioral disorders Parental refusal to participate in study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the dosage of intravenous propofol after premedication with intranasal dexmedetomodine and ketamine and induction with IV propofol and ketamine during upper GI Endoscopy.Timepoint: To compare the dosage of intravenous propofol after premedication with intranasal dexmedetomodine and ketamine and induction with IV propofol and ketamine during upper GI Endoscopy at 10 minutes , 15 minutes , 20 minutes during endoscopy | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: ;1.Hemodynamics- HR, BP , SPO2 2.Sedation score, 3.Parental separation score. 4.Any adverse effects like desaturation, bradycardiaTimepoint: At 5 minutes, 10 minutes,15 minutes, after the premedication & every 5 minutes during endoscopy | — |
Countries
India
Contacts
Public ContactJasmin Bulbul
Institute of Liver and Biliary Sciences
Outcome results
None listed