Comparison of weaning from high flow nasal cannula versus direct transition to low flow nasal cannula in children age between 1 month to 5 years with respiratory distress in terms of improvement in respiratory rate and retraction.

Comparison of weaning from high flow nasal cannula versus direct transition to nasal prong oxygen therapy in children with respiratory distress-a randomized controlled trial. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/093274

Enrollment

136

Registered

2025-08-19

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J22- Unspecified acute lower respiratory infection

Interventions

Intervention1: Children with respiratory distress with RAS score 6 or more will start HFNC then taper: children with respiratory distress with RAS score more than or equal to 6 will start HFNC, will m

Eligibility

Inclusion criteria

Inclusion criteria: All children aged one month to completed 5 years with clinical diagnosis of respiratory distress with respiratory assessment score of 6 or more

Exclusion criteria

Exclusion criteria: Children with hemodynamic instability children who need mechanical ventilator support children with known/suspected heart disease children with known/suspected neuromuscular disorder children with suspected upper airway obstruction or foreign body children with suspected air leak children with suspected intestinal obstruction children receiving HFNC therapy via tracheostomy tube children received HFNC within 1 month children who weaned from mechanical ventilation to HFNC

Design outcomes

Primary

Measure	Time frame
To compare the efficacy between weaning from high flow nasal cannula & direct transition from high flow nasal cannula to nasal prong oxygen therapy in terms of improvement in respiratory assessment score in managing children aged 1 month (corrected) to 5 years (completed)with respiratory distressTimepoint: To compare the efficacy between weaning from high flow nasal cannula & direct transition from high flow nasal cannula to nasal prong oxygen therapy in terms of improvement in respiratory assessment score in managing children aged 1 month (corrected) to 5 years (completed)with respiratory distress	—

Measure

Time frame

To compare the efficacy between weaning from high flow nasal cannula & direct transition from high flow nasal cannula to nasal prong oxygen therapy in terms of improvement in respiratory assessment score in managing children aged 1 month (corrected) to 5 years (completed)with respiratory distressTimepoint: To compare the efficacy between weaning from high flow nasal cannula & direct transition from high flow nasal cannula to nasal prong oxygen therapy in terms of improvement in respiratory assessment score in managing children aged 1 month (corrected) to 5 years (completed)with respiratory distress

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Secondary

Measure	Time frame
To compare the following between weaning from high flow nasal cannula & direct transition from high flow nasal cannula to nasal prong oxygen therapy in terms of improvement in respiratory assessment score in managing children aged 1 month (corrected) to 5 years (completed)with respiratory distress to compare the need for invasive mechanical ventilation to compare length of hospital stay to compare the factors associated with failure to compare the adverse eventsTimepoint: From day 1 of hospital stay till discharge	—

Measure

Time frame

To compare the following between weaning from high flow nasal cannula & direct transition from high flow nasal cannula to nasal prong oxygen therapy in terms of improvement in respiratory assessment score in managing children aged 1 month (corrected) to 5 years (completed)with respiratory distress to compare the need for invasive mechanical ventilation to compare length of hospital stay to compare the factors associated with failure to compare the adverse eventsTimepoint: From day 1 of hospital stay till discharge

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Countries

India

Contacts

Public ContactDr Tamilselvan

JIPMER

drselvantg@yahoo.com9916485716

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026