Health Condition 1: Z991- Dependence on respirator
Conditions
Interventions
Intervention1: Intravenous dexmedetomidine infusion: Subject will receive continuous intravenous dexmedetomidine infusion at dose of 0.25 mcg/kg/hr to maximum dose of 0.75 mcg/kg/hr for maximum durati
Sponsors
UCMS and GTB Hospital
Eligibility
Inclusion criteria
Inclusion criteria: All children aged between 1 year to 12 year, admitted in PICU and requiring mechanical ventilation
Exclusion criteria
Exclusion criteria: 1. History of known allergy or reaction to dexmedetomidine or midazolam or fentanyl 2. Patients with neuro-paralytic disorder 3. Patients already on sedation 4. Patients with hepatic involvement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of time spent in level -3 to -4 of RASSTimepoint: From enrollment to 48 hours of study | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to achieve -3 or -4 sedation level of RASSTimepoint: From enrollment to time taken to achieve -3 or -4 level of RASS;Number of additional boluses requiredTimepoint: From enrollment to 48 hours of study;Episodes of bradycardia, hypotension and any other adverse effectTimepoint: From enrollment to 48 hours of study | — |
Countries
India
Contacts
Public ContactDr Unnati Sharma
University College of Medical Sciences and GTB hospital, Delhi
Outcome results
None listed