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Testing blood markers to check gum health in smokers and non-smokers.

Cell free DNA and its receptor TLR9: a possible marker for periodontal disease status in smokers and non-smokers. - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/08/093243
Enrollment
60
Registered
2025-08-19
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Collection of GCF samples: Collection of GCF samples from patients with periodontitis and smokers with periodontitis and comparison of the cfDNA levels. Control Intervention1: Smoking:

Sponsors

Dr Sruthy Sudir
Lead Sponsor
Dr Sruthy Sudir
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Group 1:Periodontal health with intact periodontium (healthy) Group 2:Subjects with Stage II-IV generalized periodontitis. Group 3: Subjects with the habit of smoking nicotine cigarettes with periodontitis

Exclusion criteria

Exclusion criteria: Patients with any systemic disease. Former smokers. People using other forms of smoking along with cigarettes. Patients undergoing orthodontic treatment. Pregnancy or lactation. Patients with history of periodontal therapy within past 3 months. Patients with history of antibiotic intake within past 3 months. Patients with history of anti-inflammatory drug therapy within 3 months. Patients with any intra oral lesions.

Design outcomes

Primary

MeasureTime frame
Difference in salivary or gingival crevicular fluid (GCF) levels of cell-free DNA and TLR9 expression between smokers, non-smokers, and healthy controls, and their correlation with periodontal disease severity.Timepoint: Difference in salivary or gingival crevicular fluid (GCF) levels of cell-free DNA and TLR9 expression between smokers, non-smokers, and healthy controls, and their correlation with periodontal disease severity.—

Secondary

MeasureTime frame
Changes in periodontal clinical parameters (PPD, CAL, BOP, PI, GI) after therapy. Correlation between cfDNA/TLR9 levels and disease severity. Differences in cfDNA/TLR9 changes between smokers and non-smokers over time. Diagnostic accuracy of cfDNA/TLR9 in distinguishing disease status and predicting treatment response.Timepoint: Difference in salivary or gingival crevicular fluid (GCF) levels of cell-free DNA and TLR9 expression between smokers, non-smokers, and healthy controls, and their correlation with periodontal disease severity.—

Countries

India

Contacts

Public ContactDr Sanjeela Guru

Vydehi Institute of Dental Sciences and Research Centre

sanjeelaguru@yahoo.com7259665551

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026