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What makes Leptospirosis severe and how can we predict it with SPiRO score.

Mortality and severity predictors of Leptospirosis and usefulness of SPiRO score. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/08/093153
Enrollment
267
Registered
2025-08-18
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A279- Leptospirosis, unspecified

Interventions

Intervention1: Nil: Nil

Sponsors

Department of General Medicine
Lead Sponsor
Department of Emergency Medicine
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1) Adults aged 18 years and above 2) Patients diagnosed with suspected, probable or confirmed leptospirosis based on WHO 2003 diagnostic criteria. 3) Hospitalized patients (those admitted for treatment and management of leptospirosis- related complications) 4) Availability of laboratory and clinical data, including parameters such as presence of Jaundice, Hemoptysis, Hypotension, Hematocrit levels, WBC count and platelet count.

Exclusion criteria

Exclusion criteria: 1) Co-Infections ? Patients with other infectious diseases that may affect prognosis (e.g., dengue, malaria). 2) Age ? Below 18 years not included. 3) Clinical and Laboratory Data ? Cases lacking sufficient clinical or laboratory data. 4) Pre-existing Medical Conditions ? Patients with thalassemia, chronic kidney disease, or other serious underlying conditions. 5) Patients on Immunosuppressive Therapy ? Those undergoing chemotherapy or immunosuppressive treatments that may alter the disease presentation.

Design outcomes

Primary

MeasureTime frame
To identify clinical predictors of disease severity and mortality in Leptospirosis.Timepoint: 4 weeks

Secondary

MeasureTime frame
1) To evaluate the prognostic utility of the Spiro Score in predicting disease severity & mortality in leptospirosis. 2) Analyze patient outcomes based on SPiRO Score categories to determine its practical usefulness. Timepoint: 4 weeks

Countries

India

Contacts

Public ContactPrithvishree Ravindra

Kasturba Medical College, Manipal

nitin.bhat@manipal.edu9008576103

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026