This study compares how well two medicines that is tramadol (a painkiller) and dexamethasone (which helps reduce swelling), works when injected under the gum, to see which one better helps with pain, swelling, and other problems after the surgical removal of a lower wisdom tooth.

Comparison Of Efficacy Of Submucosal Injection Of Tramadol Vs Dexamethasone In Reducing Post Operative Sequelae In Impacted Mandibular Third Molar Extraction : A Prospective, Randomised, Placebo Controlled, A Triple Blind Study. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/093149

Enrollment

Registered

2025-08-18

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: TRAMADOL: SUBMUCOSAL INJECTION OF 50mg/ml (1ml) TRAMADOL IN MANDIBULAR THIRD MOLAR DISIMPACTION CASES o Intervention2: DEXAMETHASONE: SUBMUCOSAL INJECTION OF 4mg/ml (1ml) DEXAMETHASONE

Eligibility

Inclusion criteria

Inclusion criteria: 1 Above 18 years of age, any sex. 2 Impacted mandibular third molar (which require transalveolar extraction) with Pederson difficulty index- moderately difficult (5-7) 3 American Society of Anesthesiologists (physical status classification)- class 1

Exclusion criteria

Exclusion criteria: ? Age below 18 years ? Patient with history of any systemic illness ? Patients with pericoronitis or local acute infection at the time of surgery. ? Pregnancy or lactating women. ? Drug allergy to tramadol and dexamethasone.

Design outcomes

Primary

Measure	Time frame
1) Reduction in swelling. 2) Improvement in mouth opening. 3) Reduction in pain. Timepoint: postoperative 1st, 3rd and 7th day	—

Secondary

Measure	Time frame
1. To compare rescue analgesia needed by the patient (duration & frequency) after submucosal injection of tramadol & dexamethasone postoperatively on 1st, 3rd & 7th day. 2. Side effects of drugs : Nausea, vomiting, burning & dizziness etc Timepoint: 1st 3rd & 7th postoperative day	—

Countries

India

Contacts

Public ContactCHATOI SOCIA

MAULANA AZAD INSTITUTE OF DENTAL COLLEGE

Spankajomfs@gmail.com9654958541

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026