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comparison of efficacy of different pulp capping agent on human teeth

Comparative evaluation of MTA, combination of Chitosan-Nanohydroxyapatite and combination of Chitosan -Nanohydroxyapatite -Collagen on formation of dentinal bridge and inflammatory response of pulp when used as a direct pulp capping agent on human teeth.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/093121
Enrollment
54
Registered
2025-08-14
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Combination of chitosan and nanohydroxyapatite: not applicable Intervention2: Combination of Chitosan, Nanohydroxyapatite and Collagen : not applicable Control Intervention1: Mineral tr

Sponsors

Dr mrunal shind
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Pt. between age group of 15 to 25 years will be seleted from Dept. of orthodontic and dentofacial orthopedics ,bhararti vidyapeeth demeed university dental college and hospital,pune. Inclusion citeria: 1) Sound permanent premolar with closed apces 2)No carious lesion 3)Normal response to pulp vitality test

Exclusion criteria

Exclusion criteria: 1) Fracture teth

Design outcomes

Primary

MeasureTime frame
Asymptomatic vital permanent teeth with exposed pulp can be treated successfully by direct pulp capping using combination of chitosan-nanohydroxyapetite-collagen thereby allowing patient to retained teeth longer and at lower cost than alternative more invasive intervention like Root Canal Treatment.Timepoint: sample will be assessed histopathologically under research microscope at 5th,28th and on 90th day.

Secondary

MeasureTime frame
Repair progress of pulp tissue will be assessed by checking i)dentinal bridge formation ii)inflammatory response after using different direct pulp capping material at different time interval.Timepoint: 1)Good dentinal bridge will formed at 28 th day 2)Inflammatory response of pulp tissue will be present at 5 th day, Reduced inflammatory response of pulp tissue at 28 th day, Inflammatory response of pulp tissue will be absent at 90 th day.

Countries

India

Contacts

Public ContactDr Mrunal Shinde

bharati vidyapeeth deemed to be university dental college and hospital ,pune.

varsha.pandit@bharatividyapeeth.edu9850601530

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026