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Red Blood Cell (RBC) Genotyping - A Boon For Transfusion Dependent Patients

Red Blood Cell (RBC) Genotyping - A Panacea For Transfusion Dependent Patients - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/093101
Enrollment
1000
Registered
2025-08-14
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D55-D59- Hemolytic anemias

Interventions

Intervention1: Genotype matched packed red cells: both patient and donor genotyped and matched transfusion is done for 5 years Intervention2: Nil: Nil Control Intervention1: Regular cross match compat

Sponsors

Indian Council of Medical Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Transfusion dependent Patients, Antenatal Mother Rh Negative Rh Positive Antenatal Mothers with ICT positive Hemolytic disease of fetus and new born Willing to participate in the Study

Exclusion criteria

Exclusion criteria: Transfusion dependent Patients who are not Willing to participate in the Study

Design outcomes

Primary

MeasureTime frame
to create indigenous blood group genome sequencing among south indian populationTimepoint: Baseline genotyping IAT will be done every 6 months—

Secondary

MeasureTime frame
To study the immune regulation among transfusion dependent patients To determine the association between HLA & allo antibody formation among transfusion dependent patientsTimepoint: Baseline HLA After transfusion of Red cells Interleukins tested—

Countries

India

Contacts

Public ContactDr G Kavitha

Madras Medical College

kavitharaja2006@gmail.com9003017065

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026