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A study to see which muscle recovery medicine helps the gut recover sooner after laparoscopic surgery.

Comparison of Neuromuscular reversal with Neostigmine and Glycopyrrolate verses Sugammadex on bowel motility recovery after Laparoscopic colorectal surgery.A prospective Randomised study. - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/093072
Enrollment
60
Registered
2025-08-14
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: C180- Malignant neoplasm of cecum Health Condition 3: C182- Malignant neoplasm of ascending colon Health Condition 4: C181- Malignant neoplasm of appendix Health Condition 5: C187- Malignant neoplasm of sigmoid colon Health Condition 6: C184- Malignant neoplasm of transverse colon Health Condition 7: C183- Malignant neoplasm of hepatic flexure Health Condition 8: C185- Malignant neoplasm of splenic flexure Health Condition 9: C186- Malignant neoplasm of

Interventions

Intervention1: Sugammadex: Dose-2-4mg/kg body weight based on TOF COUNT. Given intravenously once after completion of surgery and return of spontaneous breathing. Return of Bowel activity analysed pos

Sponsors

Priyanka Kumari
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients with ASA physical status I, II, or III. 2 Patients aged 18 years and above of either sex undergoing laparoscopic colorectal surgery. 3 Patients able to comprehend and willing to participate. 4 Patients scheduled for neuromuscular blockade reversal with either Neostigmine-glycopyrrolate or Sugammadex.

Exclusion criteria

Exclusion criteria: 1 Patients who refuse to participate. 2 Patients with known hypersensitivity to neostigmine, glycopyrrolate, or sugammadex. 3 Patients with severe renal or hepatic dysfunction. 4 Patients with pre-existing bowel motility disorders. 5 Patients with significant cognitive impairment.

Design outcomes

Primary

MeasureTime frame
Return of Bowel motility 24 hour postoperatively.Timepoint: Return of Bowel motility 24 hour postoperatively.

Secondary

MeasureTime frame
Time to first oral intake. Evaluate postoperative nausea and vomiting. Assess total opioid consumption within 24hrs postoperatively.Timepoint: first 24 hour postoperatively.

Countries

India

Contacts

Public ContactProf Dr Vinod Kumar Verma

Indira Gandhi Institute of Medical Sciences,Patna.

drvvinodv@gmail.com8292000111

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026