Health Condition 1: E118- Type 2 diabetes mellitus with unspecified complications
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Variant Bio, USA
Eligibility
Inclusion criteria
Inclusion criteria: Type 2 Diabetes and Lean individuals aged 18 years or above, clinically diagnosed with type 2 diabetes, and a body mass index more than 16 and less than 23 Type 2 Diabetes and Non lean individuals aged 18 years or above clinically diagnosed with type 2 diabetes and a body mass index greater than or equal to 23 Non diabetes individuals aged 18 years or above have a body mass index more than 16 and have never been clinically diagnosed with diabetes While they should be generally healthy individuals and may have been diagnosed with other non severe conditions that are not diabetes
Exclusion criteria
Exclusion criteria: Refuse or are unable to understand or give consent Have a condition(s) that may make participation unsafe Are under guardianship or trusteeship Are pregnant or breastfeeding Have a clinical diagnosis of type 1 diabetes, MODY, or LADA (confirmatory tests not required, only exclude if clinical diagnosis has already been made) Are unable to return for biological sampling (if necessary)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The study will be a comprehensive map of genetic variants associated with the risk of lean and non lean diabetes and comorbidities in an Indian populationTimepoint: Three years | — |
Secondary
| Measure | Time frame |
|---|---|
| This study will be to map genetic variants to quantitative molecular traits such as biomarkers, gene expression, gene splicing, proteins, and metabolites which will allow us to translate our genetic findings to a molecular mechanism associated with disease susceptibility or progressionTimepoint: Three years | — |
Countries
India
Contacts
Public ContactDr R Guha Pradeepa
Madras Diabetes Research Foundation
Outcome results
None listed