Health Condition 1: G938- Other specified disorders of brain
Conditions
Interventions
Intervention1: Repetitive Transcranial Magnetic stimulation (rTMS): Stroke patients with 7 days of Repetitive Transcranial Magnetic stimulation (rTMS) intervention. The treatment protocol involves adm
Sponsors
NIMHANS
Eligibility
Inclusion criteria
Inclusion criteria: Patient with ischemic stroke (based on TOAST criteria) 1. with upper limb motor impairment hemiplegia/monoplegia (based on MRC scale) 2. in early sub-acute phase of stroke 3. age range 18-60 years old 4. anterior circulation stroke 5. with moderate and severe disability modified Rankin Scale (mRS) score ranges from 2 to 5 6. with moderate and severe stroke severity National Institutes of Health Stroke Scale (NIHSS) 5 to 42
Exclusion criteria
Exclusion criteria: 1. Patients who i. are unable to cooperate due to global aphasia ii. are having cerebral venous thrombosis iii. are in ICU ventilators, cardio-respiratory distress iv. are having hemorrhagic stroke v. are having Primary Psychiatric disorders 2. Patients have contraindications to TMS, such as those who i. had a past history or family history of seizures and epilepsy ii. have epileptic discharge in EEG iii. Had a H/O LOC due to seizures and brain tumors iv. have metal implants on the head and neck such as surgical clips, dental implants, cochlear implants, stents in the head and neck v. have undergone decompressive craniotomy vi. having a cardiac pacemaker or cardiac stent vii. are pregnant viii. had a H/O cardiovascular disease such as Ischemic Heart Disease with low ejection fraction and cardiac failure ix. have a history of brain tumor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effect of rTMS in post-stroke patients in terms of Clinical outcome measures using BI- Barthel Index, MRS-Modified Rankin Scale, NIHSS- National Institute of Health Stroke Scale, WMFT- Wolf Motor Function Test Timepoint: Baseline- Preintervention Day -1 Postintervention Day-7 | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the effect of rTMS in post-stroke patients in terms of Neurophysiological measures using Single-pulse and paired-pulse TMS measures, Heart Rate Variability Measures (HRV) and Electroencephalographic measures (EEG) Timepoint: Baseline- Preintervention Day -1 Postintervention Day-7 | — |
Countries
India
Contacts
Public ContactDr Kaviraja Udupa
National Institute of Mental Health and Neurosciences(NIMHANS))
Outcome results
None listed