Comparing efficacy and safety of two drugs, tramadol and buprenorphine, given through a catheter in epidural space in lower spine for post operative pain relief.

Efficacy and safety of tramadol versus buprenorphine administrated epidurally for postoperative pain relief - a prospective comparative study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092983

Enrollment

Registered

2025-08-13

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M20-M25- Other joint disorders Health Condition 2: M175- Other unilateral secondary osteoarthritis of knee Health Condition 3: N83- Noninflammatory disorders of ovary, fallopian tube and broad ligament

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Epidural Tramadol: 1 mg per kilograms of body weight in 10 ml normal saline. Used as an analgesic. Control Interv

Eligibility

Inclusion criteria

Inclusion criteria: Patient willing to give written informed consent American society of Anaesthesiologist class 1 and class 2 Patients undergoing elective and emergency surgeries

Exclusion criteria

Exclusion criteria: Patient refusal for combined spinal epidural anaesthesia Pregnant and lactating women Patient with hepatic and renal dysfunction Patients allergic to tramadol or buprenorphine Patients with COPD Local infection at epidural site Vertebral anomalies Coagulopathies Neurological diseases Psychiatric illness BMI more than 35 kg/m

Design outcomes

Primary

Measure	Time frame
Post operative pain relief in visual analouge scaleTimepoint: At baseline, 30 minutes, 60 minutes, 90 minutes, 120 minutes, 180 minutes, 240 minutes, 300 minutes, 360 minutes. 12 hours and 24 hours	—

Secondary

Measure	Time frame
Onset of pain relief, time interval from administration of drug to beginning of noticeable pain relief in minutes.Timepoint: Calculated from baseline in minutes.;Duration of pain relief. From administration of first dose of drug till requirement of second dose of drug.Timepoint: At baseline, 30 minutes, 60 minutes, 90 minutes, 120 minutes, 180 minutes, 240 minutes, 300 minutes, 360 minutes. 12 hours & 24 hours	—

Measure

Time frame

Onset of pain relief, time interval from administration of drug to beginning of noticeable pain relief in minutes.Timepoint: Calculated from baseline in minutes.;Duration of pain relief. From administration of first dose of drug till requirement of second dose of drug.Timepoint: At baseline, 30 minutes, 60 minutes, 90 minutes, 120 minutes, 180 minutes, 240 minutes, 300 minutes, 360 minutes. 12 hours & 24 hours

—

Countries

India

Contacts

Public ContactDr B Jalakandan

Department of Anesthesia, Apollo KH Hospital

dr_jalakandan@yahoo.co.in9994976064

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026