Health Condition 1: E282- Polycystic ovarian syndrome
Conditions
Interventions
Intervention1: Blood sample: Blood sample will be collected from each subject at two time points. A fasting blood sample and a post 75 g OGTT (2h hour) blood sample.
Intervention2: Nil: Nil
Sponsors
Endocrinology Department Development Fund
Eligibility
Inclusion criteria
Inclusion criteria: CASES: ANY FEMALE FULFILLING ROTTERDAM CRITERIA FOR DIAGNOSIS OF PCOS CONTROLS: ANY FEMALE WITH REGULAR MENSTRUAL CYCLES
Exclusion criteria
Exclusion criteria: EXCLUSION CRITERIA: 1.Hyperprolactinemia 2.Thyroid dysfunction 3.Cushing s syndrome and exogenous steroid therapy 4.Androgen-secreting tumours 5.Non classic congenital adrenal hyperplasia 6.Diabetes Mellitus 7.Patients on treatment for insulin resistance 8.Patients on treatment with oral contraceptive pills 9.Pregnant and lactating females 10.Patients who took antibiotics/ prebiotics in previous 1 month 11.Gastrointestinal disease (Ulcerative Colitis, Crohn s disease, Malignancy, Colitis, Enteritis) 12.Patients with either acute or chronic systemic illnesses
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare alpha diversity of gut microbiome between treatment naive PCOS patients with age and BMI matched controlsTimepoint: at the completion of study | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare beta diversity indices of gut microbiome between treatment naive PCOS patients with age & BMI matched controls 2. To study correlation between hormonal & metabolic markers & microbial diversity indices. 3. To study & compare relative abundances of bacteria between treatment naive PCOS patients with age & BMI matched controls 4. To study correlation between clinical parameters & microbial diversity indices.Timepoint: At the completion of the study | — |
Countries
India
Contacts
Public ContactDr. Nikhil Bhagwat
TNMC AND NAIR HOSPITAL
Outcome results
None listed