Correlation between patients receiving different duration of antibiotics and postoperative infectious complications in patients undergoing Pancreaticoduodenectomy

Antibiotic duration and infectious complications in patients undergoing Pancreaticoduodenectomy - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092949

Enrollment

Registered

2025-08-12

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C15-C26- Malignant neoplasms of digestive organs

Interventions

Intervention1: Antibiotic duration in patients undergoing pancreaticoduodenectomy: In patients undergoing pancreaticoduodenectomy(Whipples procedure), are divided into two groups. Both the groups woul

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient willing to give consent for being participant in the study 2.Patient undergoing WHIPPLE- pancreaticoduodenectomy for benign and malignant etiology 3.Inj Piptaz( piperacillin + tazobactam) 4.5g IV four times a day empirically. Antibiotic will be replaced accordingly to intraoperative bile culture and sensitivity 4. Renal dose adjustment of Injection Piperacillin + Tazobactam will be considered in patients with renal compromise

Exclusion criteria

Exclusion criteria: 1.Patient not giving informed consent 2.Patients undergoing total pancreatectomy. enucleation, distal pancreatectomy 3.Post operative complications other than infectious complications 4.If patients of Group A develop prolonged septic complications requiring extended antibiotic course will either be excluded or be accounted in group B 5. Patient developing organ failure, requiring mechanical ventilation or pressure support or ICU admission or operated outside or lost to follow up/absconded

Design outcomes

Primary

Measure	Time frame
To assess the effect of the antibiotic duration in two groups 4days (96hr) and 8 days(192hr) undergoing pancreaticoduodenectomy with infectious complications mainly surgical site infection (SSI) postoperativelyTimepoint: TILL 4 WEEKS	—

Secondary

Measure	Time frame
To see reduction of other post operative infectious complications such as intra abdominal abscess, post operative pancreatitis, cholangitis, and non specific such as pneumonia, urinary tract infection , sepsis and length of hospital stayTimepoint: TILL 3 MONTHS	—

Countries

India

Contacts

Public ContactRapolu Sri Chandana Deepthi

PGIMER CHANDIGARH

kamanlil@yahoo.com7087009644

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026