Comparing Two Intravenous Drugs to Prevent Surges in Blood pressure and Heart Rate During Skull Pin Placement in Brain Tumor Surgery.

Intravenous Dexmedetomidine (1mcg/kg) versus Intravenous Magnesium Sulphate (50mg/kg)for attenuation of the Hemodynamic Stress Response During Skull Pin Insertion in Patients with Intracranial Neoplasms Undergoing Elective Craniotomy: A Prospective Randomized Comparative Study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092888

Enrollment

Registered

2025-08-12

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D496- Neoplasm of unspecified behavior of brain

Interventions

Intervention1: Intravenous Magnesium Sulphate 50 mg/kg: Intravenous Magnesium Sulphate 50 mg/kg will be administered before pin insertion and hemodynamic parameters will be monitored. Control Interven

Eligibility

Inclusion criteria

Inclusion criteria: Patients belonging to ASA II aged between 18 to 60 years with intracranial neoplasms undergoing elective craniotomy.

Exclusion criteria

Exclusion criteria: Patients with known history of allergy to the study drugs. Patients in hypovolemia, heart blocks etc. Patients undergoing emergency surgeries. Patients with more than 20% drop in hemodynamic parameters after study drug administration Patients with hypermagnesemia.

Design outcomes

Primary

Measure	Time frame
1.Measure and compare heart rate between two groups. 2.Measure and compare systolic blood pressure, diastolic blood pressure and mean arterial pressure between two groups.Timepoint: Before induction, five minutes after intubation, before pin insertion, at the time of pin insertion, one minute, five minutes, 10 minutes, 20 minutes, 30 minutes after pin insertion.	—

Secondary

Measure	Time frame
1.To compare the total fentanyl requirement up to 30 minutes post pin insertion between two groups. 2. Compare the incidence of adverse effects related to study drugs in both groups.Timepoint: Up to 30 minutes post pin insertion.	—

Countries

India

Contacts

Public ContactDr.Anitha Diwakar

Sri Sathya Sai Institute of Higher Medical Sciences

choudhary.vrushali@gmail.com8308836873

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026