Effect of Deep Gum Cleaning on Natural Proteins Linked to Gum Health

Effect of scaling and root planning On the expression of neuregulin-4 Levels and its receptor erbb4 in gcf in Stage ii periodontitis patients with And without type 2 diabetis mellitus. - nil

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092876

Enrollment

Registered

2025-08-12

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E116- Type 2 diabetes mellitus with other specified complications

Interventions

Intervention1: Effect of scaling and root planning on expression of Neuregulin 4 and its receptor ErbB4 in GCF: In Periodontitis patients without diabetis Intervention2: PERIODONTITIS AND PERIODONTITI

Eligibility

Inclusion criteria

Inclusion criteria: GROUP 1:Presence of minimum 16 natural teeth. Systemically healthy patients with no signs of gingival inflammation defined by gingival index score<0.5 and without periodontal clinical attachment loss and bone loss. group2: Systemically healthy patients with periodontitis clinically diagnosed based on American Academy Periodontology (2017) classification 7 having clinical attachment loss greater than or equal to 3mm in thirty percent of the sites and probing pocket depth greater than or equal to4 mm with at least 2 teeth. group 3: Periodontitis patients (based on American Academy Periodontology 2017 classification) 7 with well controlled T2DM Patients with type 2 diabetes diagnosed at-least one year prior to the study using diagnostic criteria of the American Diabetes Association.

Exclusion criteria

Exclusion criteria: Patients with any other systemic disease accompanying type 2 DM. Patients with type 1 DM. Pregnancy or lactation. Current or former smokers. Patients with history of periodontal therapy within past 6 months. Patients with history of antibiotic intake within past 3 months. Patients with history of anti-inflammatory drug therapy within 3 months. Patients taking any other medications excluding medication for DM. Patients with any intra oral lesions.

Design outcomes

Primary

Measure	Time frame
change in neuregulin 4 levels in GCFTimepoint: baseline,3 months	—

Secondary

Measure	Time frame
change in periodontal parameters,corelatin between neuregulin 4 and diabetes mellitusTimepoint: baseline, 3 months	—

Countries

India

Contacts

Public ContactDr. Sai Pragathi

Vydehi institute of dental sciences and research centre

shruthi_s1984@yahoo.com9886824276

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026