A comparative study of two types of anaesthesia for postoperative disorientation in young females undergoing laparoscopic gallbladder removal surgery

Comparative analysis of isoflurane and propofol based total intravenous anaesthesia for postoperative delirium in young adults undergoing laparoscopic cholecystectomy - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092822

Enrollment

Registered

2025-08-11

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K80- Cholelithiasis

Interventions

Intervention1: Induction by Inhalational and Total Intravenous Anaesthesia: Induction by Isoflurane inhalational anaesthesia of Minimum Alveolar Concentration 1-1.5 to one group of participants and Pr

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA 1 and ASA 2 patients 2. Patients scheduled for laparoscopic cholecystectomy 3. Patients between age 18 to 40 years of age and female sex 4. Written informed consent

Exclusion criteria

Exclusion criteria: 1. Presence of pre existing cognitive or neurological disorders. 2. Presence of emergencies or urgent surgeries. 3. History of substance abuse or dependence. 4. Presence of significant comorbidities e.g. severe cardiovascular disease, renal failure, advanced hepatic dysfunction, uncontrolled diabetes mellitus, severe respiratory disease, uncontrolled hypertension. 5. ASA grade 3 and 4 6. Pregnant or breast feeding 7. Concurrent surgeries 8. Inability to provide informed consent or participate in follow up. 9. Intra operative conversion to open cholecystectomy. 10. Receipt of regional anaesthesia techniques along side general anaesthesia.

Design outcomes

Primary

Measure	Time frame
A prospective randomised control trial to compare the incidence of post operative delirium following laparoscopic cholecystectomy under Isoflurane inhalational anaesthesia and Propofol based Total Intravenous Anaesthesia.Timepoint: The primary outcome will be the incidence of delirium with in first 2 post operative days. The delirium will be assessed by Confusion Assessment Method once a day between 3 pm to 5 pm. If the patient is discharged with in 2 days after surgery, the last assessment will be performed on the day of discharge.	—

Measure

Time frame

A prospective randomised control trial to compare the incidence of post operative delirium following laparoscopic cholecystectomy under Isoflurane inhalational anaesthesia and Propofol based Total Intravenous Anaesthesia.Timepoint: The primary outcome will be the incidence of delirium with in first 2 post operative days. The delirium will be assessed by Confusion Assessment Method once a day between 3 pm to 5 pm. If the patient is discharged with in 2 days after surgery, the last assessment will be performed on the day of discharge.

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Secondary

Measure	Time frame
1. To observe duration , severity and type of post operative delirium. 2. To assess the post operative pain. 3. To record the frequency and dose of opioid rescue medication e.g. Morphine or Tramadol for breakthrough pain.Timepoint: Observation of duration, severity and type of post operative delirium will be done with in first 2 post operative days and assessment of pain at 2, 6, 12, 24 hours post operatively by Visual Analog Scale.	—

Measure

Time frame

1. To observe duration , severity and type of post operative delirium. 2. To assess the post operative pain. 3. To record the frequency and dose of opioid rescue medication e.g. Morphine or Tramadol for breakthrough pain.Timepoint: Observation of duration, severity and type of post operative delirium will be done with in first 2 post operative days and assessment of pain at 2, 6, 12, 24 hours post operatively by Visual Analog Scale.

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Countries

India

Contacts

Public ContactProf A P Singh

Banaras Hindu University Varanasi

bhuapsingh@gmail.com9839412975

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026