Apelin and Adiponectin levels in patients with periodontal disease and hypertension and its relation to cognition before and after ultrasonic scaling.

Apelin and Adiponectin and their relation to periodontal disease, hypertension and cognition before and after scaling and root planning - An observational study. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092801

Enrollment

Registered

2025-08-11

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I10- Essential (primary) hypertension

Interventions

Intervention1: Scaling and root planing: Salivary and serum Apelin and Adiponectin levels, neuropsychological assessment and clinical parameters will be assessed at baseline and four weeks post scalin

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients who have not received any periodontal treatment in the previous six months. 2.Patients with a diagnosis of generalized periodontitis as per World Workshop Classification criteria (2017) 3.Patients diagnosed with Hypertension as per the American College of Cardiology (ACC) and American Heart Association (AHA) guidelines (2017).

Exclusion criteria

Exclusion criteria: 1.Smokers and alcoholics. 2.Patients with systemic diseases like diabetes mellitus, cardiovascular diseases, rheumatoid arthritis, tumors, autoimmune diseases and renal diseases. 3.Pregnant and lactating females. 4.Any other systemic disease which can alter the course of periodontal disease. 5.Patients on medications like anti-inflammatory drugs, antibiotics and anti-epileptic drugs in the past 6 months. 6.Postmenopausal women.

Design outcomes

Primary

Measure	Time frame
To correlate levels of salivary & serum Apelin and Adiponectin in individuals with generalised periodontitis and Hypertension.Timepoint: At baseline and four weeks after scaling and root planing	—

Secondary

Measure	Time frame
To evaluate the effect of scaling and root planing on periodontal health, hypertension and cognition.Timepoint: At baseline and four weeks after scaling and root planing	—

Countries

India

Contacts

Public ContactDr Ashish S Nichani

The Oxford Dental college

nichaniashish@hotmail.com9845252203

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026