Comparing the environmental impact of two common anaesthetic drugs- sevoflurane and propofol on carbon dioxide emissions.

Comparative quantification of carbon dioxide emissions associated with propofol and sevoflurane based anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092764

Enrollment

Registered

2025-08-11

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Propofol based anaesthesia: Anaesthesia will be provided using a continuous intravenous infusion of propofol, titrated to clinical response, along with 60 percent nitrous oxide and 40 p

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients aged 18 years and above, with ASA PS I, II or III undergoing elective laparoscopic cholecystectomy under general anaesthesia will be recruited.

Exclusion criteria

Exclusion criteria: 1. Patients with a previous history of malignant hyperthermia. 2. Known allergy to inhalation anaesthetics/ Propofol (egg Allergy) 3. Development of significant intraoperative events like bronchospasm, hypotension and arrythmias or any other hemodynamic instability. 4. Emergency surgeries or surgeries conducted under regional anaesthesia 5. Surgeries with incomplete or missing data

Design outcomes

Primary

Measure	Time frame
The primary outcome will be the carbon equivalent emissions in kg calculated from use of propofol, sevoflurane and nitrous oxide. These emissions will be calculated based on standarised emission conversion factors for each anaesthetic agent, reflecting the carbon footprint associated with both anaesthesia techniques like propofol and sevoflurane during elective laparoscopic cholecystectomy surgeries.Timepoint: After every 15 minutes post induction till the completion of surgery.	—

Measure

Time frame

The primary outcome will be the carbon equivalent emissions in kg calculated from use of propofol, sevoflurane and nitrous oxide. These emissions will be calculated based on standarised emission conversion factors for each anaesthetic agent, reflecting the carbon footprint associated with both anaesthesia techniques like propofol and sevoflurane during elective laparoscopic cholecystectomy surgeries.Timepoint: After every 15 minutes post induction till the completion of surgery.

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Secondary

Measure	Time frame
Total Consumption of Anaesthetic Agents per Case: The total volume of propofol, sevoflurane, & nitrous oxide consumed per case will be estimated & compared between the two anaesthesia techniques. Wastage of Propofol per Case: The volume of propofol wasted (drawn but unused, or residual) during the procedure will be quantified for the propofol group. Cost of Anaesthetic Agents per Case: The direct cost of anaesthetic agents (propofol, sevoflurane, & nitrous oxide) used per case will be estimated & compared between the two groups. Timepoint: After every 15 minutes post induction till the completion of surgery.	—

Measure

Time frame

Total Consumption of Anaesthetic Agents per Case: The total volume of propofol, sevoflurane, & nitrous oxide consumed per case will be estimated & compared between the two anaesthesia techniques. Wastage of Propofol per Case: The volume of propofol wasted (drawn but unused, or residual) during the procedure will be quantified for the propofol group. Cost of Anaesthetic Agents per Case: The direct cost of anaesthetic agents (propofol, sevoflurane, & nitrous oxide) used per case will be estimated & compared between the two groups. Timepoint: After every 15 minutes post induction till the completion of surgery.

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Countries

India

Contacts

Public ContactDr Deepika Gupta

Government Medical College, sector 32 , Chandigarh

swatirohit604@gmail.com9646004171

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026