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Assessing the brain blood flow control and carbon dioxide response before and after supretentorial brain tumor surgery.

Perioperative assessment of dynamic cerebral autoregulation and vasomotor reactivity using transcranial doppler in patients undergoing elective craniotomy for supratentorial tumour excision - A Prospective study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/08/092695
Enrollment
55
Registered
2025-08-08
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C710- Malignant neoplasm of cerebrum, except lobes and ventricles

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil Intervention5: Nil: Nil Intervention6: Nil: Nil Intervention7: Nil: Nil

Sponsors

Jawaharlal Institute of Postgraduate Medical Education and Research Intramural fund
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA GRADE 1 AND 2 GCS MORE THAN 13

Exclusion criteria

Exclusion criteria: Absence of good bilateral Transcranial doppler windows Recurrent or Residual intracranial tumours Hemodynamic instability Patients requiring ventilatory support before surgery H/o syncope or carotid artery disease H/o cerebrovascular accident Vascular disorders

Design outcomes

Primary

MeasureTime frame
To assess and compare the change in dynamic cerebral autoregulation using THRR before and after supratentorial tumour excision.Timepoint: Preoperative day and Postoperative day one to five post supretentorial tumour excision.—

Secondary

MeasureTime frame
To assess & compare the Co2 reactivity, vasomotor reactivity & cerebral vasodilatory reserve before & after supratentorial tumour excision.Timepoint: Preoperative day & Postoperative day one to five post supretentorial tumour excision.;To assess the effect of tumour size on cerebral autoregulation pre & post operativelyTimepoint: Preoperative day & Postoperative day one to five post supretentorial tumour excision.;To assess the risk factors associated with deranged cerebral autoregulation in supratentorial tumours.Timepoint: Preoperative day & Postoperative day one to five post supretentorial tumour excision.;To assess neurological outcome of the patient at 90 days using GOS-E score.Timepoint: 90 days postoperatively—

Countries

India

Contacts

Public ContactJayanth R Seshan
rsriharivignesh@gmail.com9940630956

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026