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A Functional MRI Study Evaluating the Neuromodulatory Effects of Low-Level Laser Therapy in Patients with Temporomandibular Joint Disorders.

Neuromodulatory Effects of Low-Level Laser Therapy (LLLT) in Temporomandibular Joint (TMJ) Disorders: A Functional MRI study - NIL

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/092671
Enrollment
15
Registered
2025-08-08
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M266- Temporomandibular joint disorders

Interventions

Intervention1: Low-level LASER therapy with 810 nm wavelength of LASER: LLLT will be applied to TMJ-affected areas using a laser device : 810 nm diode laser, with continuous wave, contact mode with

Sponsors

Harshita Tiwari
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients clinically diagnosed with TMD as per the latest version of RDC or TMD. 2.Patients willing to participate who have given consent for the study. 3. Patients with blood parameters (CBC, RA Factor and Uric Acid) levels within normal limits.

Exclusion criteria

Exclusion criteria: 1.Subjects with history of orthodontic or prosthodontic treatment. 2.Subjects with history of trauma or surgery of the TMJ. 3.Subjects with history of previous treatment for the same complaint. 4. Subjects with OPG showing degenerative changes in the mandibular condyle e.g. rheumatoid arthritis, osteoarthritis.

Design outcomes

Primary

MeasureTime frame
Clinical assessments of Pain intensity using the Visual Analog Scale and Jaw functional limitation using the Jaw Functional Limitation Scale will be done preoperatively by a trained observer. Timepoint: Baseline, 4 week

Secondary

MeasureTime frame
1.To evaluate changes in neural activity in key pain-related brain regions (e.g., anterior cingulate cortex, insula, prefrontal cortex) following LLLT treatment in TMD patients. 2.To assess the impact of LLLT on functional connectivity within pain-processing networks, including the default mode network and salience network. 3.To correlate neural changes with clinical pain scores and functional improvement in TMJ disorders. Timepoint: Baseline , 4 Week

Countries

India

Contacts

Public ContactHarshita Tiwari

Institute of medical sciences, Banaras Hindu University

adit@bhu.ac.in9451525522

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026