FindTrial
Sign In

To Compare if microscopy, culture or PCR is a better method to diagnose eye disease caused by Acanthamoeba

Optimizing diagnosis of Acanthamoeba Keratitis : A comparative study of Microscopy , Culture and PCR from a tertiary care centre of South India - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/08/092654
Enrollment
180
Registered
2025-08-08
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H168- Other keratitis Health Condition 2: H160- Corneal ulcer

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil Control Intervention1: Nil: Nil

Sponsors

Kasturba Medical College , Manipal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of any age and gender presenting with symptoms suggestive of Acanthamoeba keratitis (pain, redness, photophobia, blurred vision).

Exclusion criteria

Exclusion criteria: 1)Patients with a history of recent ocular surgery or trauma that may introduce non-Acanthamoeba pathogens. 2)Patients already receiving treatment for confirmed Acanthamoeba keratitis or any other severe ocular infection.

Design outcomes

Primary

MeasureTime frame
1)To find out diagnostic accuracy in terms of Sensitivity , Specificity, PPV, NPV and accuracy for microscopy , culture ,c-PCR for Acanthamoeba Keratitis 2)To find out proportion of Acanthamoeba Keratitis cases among clinically suspected infectious keratitisTimepoint: Baseline—

Secondary

MeasureTime frame
Identification of risk factors associated with Acanthamoeba Keratitis in terms of delayed diagnosis , contact lens use,immunosuppression etcTimepoint: Baseline—

Countries

India

Contacts

Public ContactDr Vinay Khanna

Kasturba Medical College , Manipal

vinay.khanna@manipal.edu9964426900

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026