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Improving gum surgery results with Hyaluronic acid: A study on bone healing

EFFICACY OF OPEN FLAP DEBRIDEMENT WITH 0.8% HYALURONIC ACID IN TREATMENT OF INTRABONY DEFECTS: A CLINICAL TRIAL - Nil

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/092612
Enrollment
32
Registered
2025-08-07
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: 0.8% Hyaluronic acid gel after open flap debridement in treating intrabony defects.: Hyaluronic acid (0.8% concentration) gel syringes (Periobiologics LLP, Hyderabad, Telangana, India)

Sponsors

Kothiwal dental college and research centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Probing pocket depth greater than or equal to 5 mm. 2. Clinical attachment loss greater than or equal to 3 mm. 3. Sites exhibiting evidence of intrabony defects of minimum 3 mm dimension as observed through Cone beam computed tomography (CBCT).

Exclusion criteria

Exclusion criteria: 1. Subjects who went through periodontal therapy within the previous year. 2. Subjects taking any medication which can influence the gingival response during healing. 3. Subject with any systemic disease affecting periodontium. 4. Pregnant women and lactating mothers. 5. Subjects with blood dyscrasia or bleeding disorder. 6. Smokers and tobacco chewers. 7. Subjects who cannot perform routine oral hygiene procedures or do not comply with oral hygiene instructions.

Design outcomes

Primary

MeasureTime frame
1. Probing pocket depth 2. Clinical attachment level 3. Early healing index Timepoint: 1. Probing pocket depth at baseline, 3 months, 6 months 2. Clinical attachment level at baseline, 3 months, 6 months 3. Early healing index after 7 days

Secondary

MeasureTime frame
1. Intrabony defect bone fill and the crestal level of bone, using Cone beam computed tomography (CBCT). To compare results obtained in test and control groups.Timepoint: 1. Intrabony defect bone fill and the crestal level of bone, using Cone beam computed tomography(CBCT) at baseline and 6 months.

Countries

India

Contacts

Public ContactDr Narayani Singh
anubhanirwalperio@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026